Ro 3280

Discontinued Product

Ro 3280 (Cat. No. 5968) has been withdrawn from sale for commercial reasons.
Description: Potent and selective PLK1 inhibitor
Chemical Name: 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Ro 3280

Ro 3280 is a potent and selective PLK inhibitor (IC50 = 3 nM). Exhibits selectivity for PLK1 over a panel of other kinases. Inhibits growth of a range of tumor cells lines in vitro and induces apoptosis in leukemia cells. Exhibits antitumor activity in mouse colorectal and nasopharyngeal cancer models in vivo.

Technical Data for Ro 3280

M. Wt 543.61
Formula C27H35F2N7O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1062243-51-9
PubChem ID 25015677
Smiles COC1=C(C=CC(C(NC2CCN(CC2)C)=O)=C1)NC3=NC=C4N(C(C(F)(CN(C4=N3)C5CCCC5)F)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Ro 3280

References are publications that support the biological activity of the product.

Cheung et al (2013) Polo-like kinase inhibitor Ro5203280 has potent antitumor activity in nasopharyngeal carcinoma. Mol.Cancer Ther. 12 1393 PMID: 23686835

Chen et al (2012) Identification of novel, potent and selective inhibitors of Polo-like kinase 1. Bioorg.Med.Chem.Lett. 22 1247 PMID: 22172702

Wang et al (2015) Molecular targeting of the oncoprotein PLK1 in pediatric acute myeloid leukemia: RO3280, a novel PLK1 inhibitor, induces apoptosis in leukemia cells. Int.J.Mol.Sci. 16 1266 PMID: 25574601

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Keywords: Ro 3280, Ro 3280 supplier, Ro3280, Polo-like, kinases, inhibitors, inhibits, apoptosis, inducers, anticancer, PLK1, potent, selective, Kinase, Mitosis, 5968, Tocris Bioscience

Citations for Ro 3280

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Currently there are no citations for Ro 3280.

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