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Potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively). Inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Orally active.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Lewis et al (1997) Ro 32-3555, an orally active Col. inhibitor, prevents cartilage breakdown in vitro and in vivo. Br.J.Pharmacol. 121 540 PMID: 9179398
Broadhurst et al (1997) Design and synthesis of the cartilage protective agent (CPA, Ro32-3555). Bioorg.Med.Chem.Letts. 7 2299
Brewster et al (1998) Ro 32-3555, an orally active Col. selective inhibitor, prevents structural damage in the SRT/ORT mouse model of osteoarthritis. Arthrit.Rheumat. 41 1639
Keywords: Ro 32-3555, Ro 32-3555 supplier, Ro32-3555, MMP, matrix, metalloproteinase, metalloprotease, collagenase, potent, specific, selective, MMP-1, MMP-13, MMP-8, proteases, proteineases, Matrix, Metalloprotease, 2916, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Ro 32-3555 include:
Przybyla et al (2013) Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells 31 1097 PMID: 23404867
Brilha (2017) Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis. Sci Rep 7 16031 PMID: 29167512
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