Ro 32-3555

Discontinued Product

Ro 32-3555 (Cat. No. 2916) has been withdrawn from sale for commercial reasons.
Description: Potent, collagenase-selective MMP inhibitor
Chemical Name: (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide
Purity: ≥97% (HPLC)
Citations (2)
Literature (1)

Biological Activity for Ro 32-3555

Potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively). Inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Orally active.

Technical Data for Ro 32-3555

M. Wt 436.55
Formula C22H36N4O5
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 190648-49-8
PubChem ID 9824350
Smiles O=[C@@](N3CCCCC3)[C@H](CC1CCCC1)[C@@H]([C@](NO)=O)CN2C(N(C)C(C)(C)C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Ro 32-3555

Certificate of Analysis / Product Datasheet
Select another batch:

References for Ro 32-3555

References are publications that support the biological activity of the product.

Lewis et al (1997) Ro 32-3555, an orally active Col. inhibitor, prevents cartilage breakdown in vitro and in vivo. Br.J.Pharmacol. 121 540 PMID: 9179398

Broadhurst et al (1997) Design and synthesis of the cartilage protective agent (CPA, Ro32-3555). Bioorg.Med.Chem.Letts. 7 2299

Brewster et al (1998) Ro 32-3555, an orally active Col. selective inhibitor, prevents structural damage in the SRT/ORT mouse model of osteoarthritis. Arthrit.Rheumat. 41 1639

View Related Products by Product Action

View all Matrix Metalloprotease Inhibitors

Keywords: Ro 32-3555, Ro 32-3555 supplier, Ro32-3555, MMP, matrix, metalloproteinase, metalloprotease, collagenase, potent, specific, selective, MMP-1, MMP-13, MMP-8, proteases, proteineases, Matrix, Metalloprotease, 2916, Tocris Bioscience

2 Citations for Ro 32-3555

Citations are publications that use Tocris products. Selected citations for Ro 32-3555 include:

Przybyla et al (2013) Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells 31 1097 PMID: 23404867

Brilha (2017) Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis. Sci Rep 7 16031 PMID: 29167512

Reviews for Ro 32-3555

There are currently no reviews for this product. Be the first to review Ro 32-3555 and earn rewards!

Have you used Ro 32-3555?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.