Ro 32-3555

Discontinued Product

Ro 32-3555 (Cat. No. 2916) has been withdrawn from sale for commercial reasons.
Cat.No. 2916 - Ro 32-3555 | C22H36N4O5 | CAS No. 190648-49-8
Description: Potent, collagenase-selective MMP inhibitor
Chemical Name: (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively). Inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Orally active.

Technical Data

M. Wt 436.55
Formula C22H36N4O5
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 190648-49-8
PubChem ID 9824350
InChI Key GFUITADOEPNRML-SJORKVTESA-N
Smiles O=[C@@](N3CCCCC3)[C@H](CC1CCCC1)[C@@H]([C@](NO)=O)CN2C(N(C)C(C)(C)C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Lewis et al (1997) Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo. Br.J.Pharmacol. 121 540 PMID: 9179398

Broadhurst et al (1997) Design and synthesis of the cartilage protective agent (CPA, Ro32-3555). Bioorg.Med.Chem.Letts. 7 2299

Brewster et al (1998) Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the SRT/ORT mouse model of osteoarthritis. Arthrit.Rheumat. 41 1639

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Keywords: Ro 32-3555, Ro 32-3555 supplier, Ro32-3555, MMP, matrix, metalloproteinase, metalloprotease, collagenase, potent, specific, selective, MMP-1, MMP-13, MMP-8, proteases, proteineases, Matrix, Metalloprotease, 2916, Tocris Bioscience

2 Citations for Ro 32-3555

Citations are publications that use Tocris products. Selected citations for Ro 32-3555 include:

Brilha (2017) Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis. Sci Rep 7 16031 PMID: 29167512

Przybyla et al (2013) Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells 31 1097 PMID: 23404867


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Literature in this Area

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