Ro 32-3555

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Cat.No. 2916 - Ro 32-3555 | C22H36N4O5 | CAS No. 190648-49-8
Description: Potent, collagenase-selective MMP inhibitor
Chemical Name: (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively). Inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Orally active.

Technical Data

M. Wt 436.55
Formula C22H36N4O5
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 190648-49-8
PubChem ID 9824350
InChI Key GFUITADOEPNRML-SJORKVTESA-N
Smiles O=[C@@](N3CCCCC3)[C@H](CC1CCCC1)[C@@H]([C@](NO)=O)CN2C(N(C)C(C)(C)C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.66 100
ethanol 43.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 436.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.45 mL 22.91 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lewis et al (1997) Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo. Br.J.Pharmacol. 121 540 PMID: 9179398

Broadhurst et al (1997) Design and synthesis of the cartilage protective agent (CPA, Ro32-3555). Bioorg.Med.Chem.Letts. 7 2299 PMID:

Brewster et al (1998) Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the SRT/ORT mouse model of osteoarthritis. Arthrit.Rheumat. 41 1639 PMID:


If you know of a relevant reference for Ro 32-3555, please let us know.

View Related Products by Product Action

View all Matrix Metalloprotease Inhibitors

Keywords: Ro32-3555 MMP matrix metalloproteinase metalloprotease collagenase potent specific selective MMP-1 MMP-13 MMP-8 proteases proteineases Matrix Metalloprotease

1 Citation for Ro 32-3555

Citations are publications that use Tocris products. Selected citations for Ro 32-3555 include:

Przybyla et al (2013) Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells 31 1097 PMID: 23404867


Do you know of a great paper that uses Ro 32-3555 from Tocris? If so please let us know.

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