You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Discontinued ProductRo 32-3555 (Cat. No. 2916) has been withdrawn from sale for commercial reasons.
Potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively). Inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Orally active.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Lewis et al (1997) Ro 32-3555, an orally active Col. inhibitor, prevents cartilage breakdown in vitro and in vivo. Br.J.Pharmacol. 121 540 PMID: 9179398
Broadhurst et al (1997) Design and synthesis of the cartilage protective agent (CPA, Ro32-3555). Bioorg.Med.Chem.Letts. 7 2299
Brewster et al (1998) Ro 32-3555, an orally active Col. selective inhibitor, prevents structural damage in the SRT/ORT mouse model of osteoarthritis. Arthrit.Rheumat. 41 1639
View Related Products by Target
View Related Products by Product Action
Keywords: Ro 32-3555, Ro 32-3555 supplier, Ro32-3555, MMP, matrix, metalloproteinase, metalloprotease, collagenase, potent, specific, selective, MMP-1, MMP-13, MMP-8, proteases, proteineases, Matrix, Metalloprotease, 2916, Tocris Bioscience
2 Citations for Ro 32-3555
Citations are publications that use Tocris products. Selected citations for Ro 32-3555 include:
Brilha (2017) Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis. Sci Rep 7 16031 PMID: 29167512
Przybyla et al (2013) Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells 31 1097 PMID: 23404867
Reviews for Ro 32-3555
There are currently no reviews for this product. Be the first to review Ro 32-3555 and earn rewards!
Have you used Ro 32-3555?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.