Ro 10-5824 dihydrochloride

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Cat.No. 2329 - Ro 10-5824 dihydrochloride | C17H20N4.2HCl | CAS No. 189744-94-3
Description: Selective D4 receptor partial agonist
Chemical Name: 5-[(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl-4-pyrimidinamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective dopamine D4 receptor partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM). Displays 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors.

Compound Libraries

Ro 10-5824 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 353.29
Formula C17H20N4.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 189744-94-3
PubChem ID 16759174
InChI Key UZHMRJRDYCRKIZ-UHFFFAOYSA-N
Smiles Cl.Cl.CC1=NC=C(CN2CCC(=CC2)C2=CC=CC=C2)C(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.5 75
water 35.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 353.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.31 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Powell et al (2003) RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology 44 473 PMID: 12646284


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Keywords: Ro 10-5824 dihydrochloride, supplier, Selective, D4, receptor, partial, agonists, Dopamine, Receptors, dopaminergic, Ro10-5824, dihydrochloride, D4, Receptors, D4, Receptors, Tocris Bioscience

Citations for Ro 10-5824 dihydrochloride

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