Ro 10-5824 dihydrochloride

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Cat.No. 2329 - Ro 10-5824 dihydrochloride | C17H20N4.2HCl | CAS No. 189744-94-3
Description: Selective D4 partial agonist
Chemical Name: 5-[(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl-4-pyrimidinamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity

Selective dopamine D4 receptor partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM). Displays 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors.

Compound Libraries

Ro 10-5824 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 353.29
Formula C17H20N4.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 189744-94-3
PubChem ID 16759174
InChI Key UZHMRJRDYCRKIZ-UHFFFAOYSA-N
Smiles Cl.Cl.CC1=NC=C(CN2CCC(=CC2)C2=CC=CC=C2)C(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 35.33 100
DMSO 26.5 75

Preparing Stock Solutions

The following data is based on the product molecular weight 353.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.31 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Powell et al (2003) RO-10-5824 is a selective DA D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology 44 473 PMID: 12646284


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View all D4 Receptor Agonists

Keywords: Ro 10-5824 dihydrochloride, Ro 10-5824 dihydrochloride supplier, Selective, D4, receptor, partial, agonists, Dopamine, Receptors, dopaminergic, Ro10-5824, dihydrochloride, 2329, Tocris Bioscience

1 Citation for Ro 10-5824 dihydrochloride

Citations are publications that use Tocris products. Selected citations for Ro 10-5824 dihydrochloride include:

Navakkode et al (2017) Bidirectional modulation of hippocampal synaptic plasticity by Dopaminergic D4-receptors in the CA1 area of hippocampus. Sci Rep 7 15571 PMID: 29138490


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Reviews for Ro 10-5824 dihydrochloride

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