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Submit ReviewRN 9893 hydrochloride
Description: Potent and selective TRPV4 antagonist
Chemical Name: N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for RN 9893 hydrochloride
RN 9893 hydrochloride is a potent and selective TRPV4 antagonist (IC50 values are 320, 420 and 660 nM for mouse, human and rat channels, respectively). Exhibits >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. Orally bioavailable.
Compound Libraries for RN 9893 hydrochloride
RN 9893 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for RN 9893 hydrochloride
| M. Wt | 536.95 |
| Formula | C21H23F3N4O5S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 2109450-40-8 |
| PubChem ID | 121513879 |
| InChI Key | ULUOUAGDTULBRZ-UHFFFAOYSA-N |
| Smiles | O=C(NC2=CC=C(S(N3CCN(C(C)C)CC3)(=O)=O)C=C2)C1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RN 9893 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.69 | 100 |
Preparing Stock Solutions for RN 9893 hydrochloride
The following data is based on the product molecular weight 536.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.86 mL | 9.31 mL | 18.62 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.72 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.86 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
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Product Datasheets for RN 9893 hydrochloride
References for RN 9893 hydrochloride
References are publications that support the biological activity of the product.
Wei et al (2015) Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg.Med.Chem.Lett. 25 4011 PMID: 26235950
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