RN 9893 hydrochloride

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Cat.No. 5678 - RN 9893 hydrochloride | C21H23F3N4O5S.HCl | CAS No. 1803003-68-0
Description: Potent and selective TRPV4 antagonist
Chemical Name: N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective TRPV4 antagonist (IC50 values are 320, 420 and 660 nM for mouse, human and rat channels, respectively). Exhibits >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. Orally bioavailable.

Technical Data

M. Wt 536.95
Formula C21H23F3N4O5S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1803003-68-0
PubChem ID 121513879
InChI Key ULUOUAGDTULBRZ-UHFFFAOYSA-N
Smiles O=C(NC2=CC=C(S(N3CCN(C(C)C)CC3)(=O)=O)C=C2)C1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.69 100

Preparing Stock Solutions

The following data is based on the product molecular weight 536.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.31 mL 18.62 mL
5 mM 0.37 mL 1.86 mL 3.72 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Wei et al (2015) Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg.Med.Chem.Lett. 25 4011 PMID: 26235950


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Keywords: RN9893 hydrochloride potent selective TRPV4 transient receptors potential channels orally bioavailable 1803003-68-0 TRPV

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Literature in this Area

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for RN 9893 hydrochloride

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