RN 9893 hydrochloride
Potent and selective TRPV4 antagonist (IC50 values are 320, 420 and 660 nM for mouse, human and rat channels, respectively). Exhibits >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. Orally bioavailable.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 536.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.86 mL||9.31 mL||18.62 mL|
|5 mM||0.37 mL||1.86 mL||3.72 mL|
|10 mM||0.19 mL||0.93 mL||1.86 mL|
|50 mM||0.04 mL||0.19 mL||0.37 mL|
References are publications that support the biological activity of the product.
Wei et al (2015) Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg.Med.Chem.Lett. 25 4011 PMID: 26235950
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.