RN 9893 hydrochloride
Potent and selective TRPV4 antagonist (IC50 values are 320, 420 and 660 nM for mouse, human and rat channels, respectively). Exhibits >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. Orally bioavailable.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 536.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.86 mL||9.31 mL||18.62 mL|
|5 mM||0.37 mL||1.86 mL||3.72 mL|
|10 mM||0.19 mL||0.93 mL||1.86 mL|
|50 mM||0.04 mL||0.19 mL||0.37 mL|
References are publications that support the biological activity of the product.
Wei et al (2015) Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg.Med.Chem.Lett. 25 4011 PMID: 26235950
If you know of a relevant reference for RN 9893 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: RN 9893 hydrochloride, RN 9893 hydrochloride supplier, RN9893, hydrochloride, potent, selective, TRPV4, transient, receptors, potential, channels, orally, bioavailable, 1803003-68-0, TRPV, 5678, Tocris Bioscience
Citations for RN 9893 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for RN 9893 hydrochloride. Do you know of a great paper that uses RN 9893 hydrochloride from Tocris? Please let us know.
Reviews for RN 9893 hydrochloride
There are currently no reviews for this product. Be the first to review RN 9893 hydrochloride and earn rewards!
Have you used RN 9893 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.