RN 1734

Pricing Availability   Qty
Description: Selective TRPV4 antagonist
Chemical Name: 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide
Datasheet
Citations (11)
Reviews
Literature (2)

Biological Activity for RN 1734

RN 1734 is a selective TRPV4 antagonist (IC50 values are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC50 values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.

Compound Libraries for RN 1734

RN 1734 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RN 1734

M. Wt 353.31
Formula C14H22Cl2N2O2S
Storage Store at +4°C
CAS Number 946387-07-1
PubChem ID 3601086
InChI Key IHYZMEAZAIFMTN-UHFFFAOYSA-N
Smiles CC(C)NCCN(C(C)C)S(C1=C(Cl)C=C(Cl)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RN 1734

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.33 100
ethanol 17.67 50

Preparing Stock Solutions for RN 1734

The following data is based on the product molecular weight 353.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.3 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets for RN 1734

Certificate of Analysis / Product Datasheet
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References for RN 1734

References are publications that support the biological activity of the product.

Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490 PMID: 19737537

Bagher et al (2012) Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone. Proc.Natl.Acad.Sci.U.S.A. 109 18174 PMID: 23071308


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Keywords: RN 1734, RN 1734 supplier, RN1734, selective, TRPV4, antagonists, transient, receptors, potential, channels, vanilloid, TRPV, 3746, Tocris Bioscience

11 Citations for RN 1734

Citations are publications that use Tocris products. Selected citations for RN 1734 include:

Tchieu et al (2017) A modular platform for differentiation of human PSCs into all major ectodermal lineages. Cell Stem Cell. 21 399 PMID: 28886367

Feetham et al (2015) The depressor response to intracerebroventricular hypotonic saline is sensitive to TRPV4 antagonist RN1734. Cephalalgia 6 83 PMID: 25954200

Albert et al (2012) TRPV4 channels mediate the infrared laser-evoked response in sensory neurons. J Neurophysiol 107 3227 PMID: 22442563

Butenko et al (2012) The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia. PLoS One 7 e39959 PMID: 22761937


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Literature in this Area

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