RN 1 dihydrochloride

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Cat.No. 4977 - RN 1 dihydrochloride | C23H29N3O2.2HCl | CAS No. 1781835-13-9
Description: LSD1 inhibitor
Chemical Name: 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride
Purity: ≥97% (HPLC)

Biological Activity

Potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50 values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.

Compound Libraries

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Technical Data

M. Wt 452.42
Formula C23H29N3O2.2HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1781835-13-9
PubChem ID 90488995
Smiles O=C(N4CCN(C)CC4)CN[C@@H]1C[C@H]1[C@]2=CC=C(OCC3=CC=CC=C3)C=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 9.05 20
DMSO 9.05 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 452.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.05 mL 55.26 mL 110.52 mL
1 mM 2.21 mL 11.05 mL 22.1 mL
2 mM 1.11 mL 5.53 mL 11.05 mL
10 mM 0.22 mL 1.11 mL 2.21 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Neelamegam et al (2012) Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem.Neurosci. 3 120 PMID: 22754608

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