RN 1 dihydrochloride

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Description: LSD1 inhibitor
Chemical Name: 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride
Purity: ≥97% (HPLC)
Citations (1)
Literature (1)

Biological Activity for RN 1 dihydrochloride

RN 1 dihydrochloride is a potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50 values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.

Compound Libraries for RN 1 dihydrochloride

RN 1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for RN 1 dihydrochloride

M. Wt 452.42
Formula C23H29N3O2.2HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1781835-13-9
PubChem ID 90488995
Smiles O=C(N4CCN(C)CC4)CN[C@@H]1C[C@H]1[C@]2=CC=C(OCC3=CC=CC=C3)C=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RN 1 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 9.05 20
DMSO 9.05 20 with gentle warming

Preparing Stock Solutions for RN 1 dihydrochloride

The following data is based on the product molecular weight 452.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.05 mL 55.26 mL 110.52 mL
1 mM 2.21 mL 11.05 mL 22.1 mL
2 mM 1.11 mL 5.53 mL 11.05 mL
10 mM 0.22 mL 1.11 mL 2.21 mL

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Product Datasheets for RN 1 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for RN 1 dihydrochloride

References are publications that support the biological activity of the product.

Neelamegam et al (2012) Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem.Neurosci. 3 120 PMID: 22754608

If you know of a relevant reference for RN 1 dihydrochloride, please let us know.

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Keywords: RN 1 dihydrochloride, RN 1 dihydrochloride supplier, RN1, dihydrochloride, LSD1, lysine-specific, demethylase, 1, histone, demethylases, monoamine, oxidases, MAOs, inhibitors, inhibits, selective, Histone, Demethylases, 4977, Tocris Bioscience

1 Citation for RN 1 dihydrochloride

Citations are publications that use Tocris products. Selected citations for RN 1 dihydrochloride include:

Llewellyn et al (2018) HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. J Neurovirol 24 192 PMID: 29256041

Do you know of a great paper that uses RN 1 dihydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.