Rizatriptan benzoate

Pricing Availability Delivery Time Qty
Cat.No. 5136 - Rizatriptan benzoate | C15H19N5.C7H6O2 | CAS No. 145202-66-0
Description: Potent 5-HT1B/1D agonist
Alternative Names: MK 462
Chemical Name: N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine benzoate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

5-HT1B/1D agonist. Antimigraine agent; attenuates effects of CGRP on light aversion in mice. Orally bioavailable.

Compound Libraries

Rizatriptan benzoate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 391.47
Formula C15H19N5.C7H6O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 145202-66-0
PubChem ID 77997
InChI Key JPRXYLQNJJVCMZ-UHFFFAOYSA-N
Smiles CN(CCC2=CNC1=CC=C(CN3N=CN=C3)C=C12)C.O=C(C4=CC=CC=C4)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.57 50
water 39.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 391.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kaiser et al (2012) Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT1B/D agonist. J.Neurosci. 32 15439 PMID: 23115181

Street et al (1995) Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors. J.Med.Chem. 38 1799 PMID: 7752204


If you know of a relevant reference for Rizatriptan benzoate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT1B Receptor Agonists

Keywords: Rizatriptan benzoate, supplier, selective, 5-HT, serotonin, 5-HT1D, 5-HT1B, receptors, agonists, Rizatriptan, benzoate, serotonergics, MK462, MK, 462, 5-HT1B, Receptors, 5-HT1D, Receptors, 5-HT1B, Receptors, Tocris Bioscience

Citations for Rizatriptan benzoate

Citations are publications that use Tocris products.

Currently there are no citations for Rizatriptan benzoate. Do you know of a great paper that uses Rizatriptan benzoate from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for Rizatriptan benzoate

Protocols

TODO: Add Protocols