Rizatriptan benzoate

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Cat.No. 5136 - Rizatriptan benzoate | C15H19N5.C7H6O2 | CAS No. 145202-66-0
Description: Potent 5-HT1B/1D agonist
Alternative Names: MK 462
Chemical Name: N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine benzoate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

5-HT1B/1D agonist. Antimigraine agent; attenuates effects of CGRP on light aversion in mice. Orally bioavailable.

Compound Libraries

Rizatriptan benzoate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 391.47
Formula C15H19N5.C7H6O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 145202-66-0
PubChem ID 77997
InChI Key JPRXYLQNJJVCMZ-UHFFFAOYSA-N
Smiles CN(CCC2=CNC1=CC=C(CN3N=CN=C3)C=C12)C.O=C(C4=CC=CC=C4)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 39.15 100
DMSO 19.57 50

Preparing Stock Solutions

The following data is based on the product molecular weight 391.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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References

References are publications that support the biological activity of the product.

Kaiser et al (2012) Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT1B/D agonist. J.Neurosci. 32 15439 PMID: 23115181

Street et al (1995) Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors. J.Med.Chem. 38 1799 PMID: 7752204


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Citations for Rizatriptan benzoate

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