Rizatriptan benzoate

Discontinued Product

Rizatriptan benzoate (Cat. No. 5136) has been withdrawn from sale for commercial reasons.
Description: Potent 5-HT1B and 5-HT1D agonist
Alternative Names: MK 462
Chemical Name: N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine benzoate
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for Rizatriptan benzoate

Rizatriptan benzoate is a 5-HT1B/1D agonist. Antimigraine agent; attenuates effects of CGRP on light aversion in mice. Orally bioavailable.

Compound Libraries for Rizatriptan benzoate

Rizatriptan benzoate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rizatriptan benzoate

M. Wt 391.47
Formula C15H19N5.C7H6O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 145202-66-0
PubChem ID 77997
Smiles CN(CCC2=CNC1=CC=C(CN3N=CN=C3)C=C12)C.O=C(C4=CC=CC=C4)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Rizatriptan benzoate

References for Rizatriptan benzoate

References are publications that support the biological activity of the product.

Kaiser et al (2012) Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT1B/D agonist. J.Neurosci. 32 15439 PMID: 23115181

Street et al (1995) Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors. J.Med.Chem. 38 1799 PMID: 7752204

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Keywords: Rizatriptan benzoate, Rizatriptan benzoate supplier, selective, 5-HT, serotonin, 5-HT1D, 5-HT1B, receptors, agonists, Rizatriptan, benzoate, serotonergics, MK462, MK, 462, Receptors, 5136, Tocris Bioscience

Citations for Rizatriptan benzoate

Citations are publications that use Tocris products.

Currently there are no citations for Rizatriptan benzoate.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.