Rizatriptan benzoate

Pricing Availability   Qty
Cat.No. 5136 - Rizatriptan benzoate | C15H19N5.C7H6O2 | CAS No. 145202-66-0
Description: Potent 5-HT1B and 5-HT1D agonist
Alternative Names: MK 462
Chemical Name: N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine benzoate
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity for Rizatriptan benzoate

Rizatriptan benzoate is a 5-HT1B/1D agonist. Antimigraine agent; attenuates effects of CGRP on light aversion in mice. Orally bioavailable.

Compound Libraries for Rizatriptan benzoate

Rizatriptan benzoate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rizatriptan benzoate

M. Wt 391.47
Formula C15H19N5.C7H6O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 145202-66-0
PubChem ID 77997
Smiles CN(CCC2=CNC1=CC=C(CN3N=CN=C3)C=C12)C.O=C(C4=CC=CC=C4)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rizatriptan benzoate

Solvent Max Conc. mg/mL Max Conc. mM
water 39.15 100
DMSO 19.57 50

Preparing Stock Solutions for Rizatriptan benzoate

The following data is based on the product molecular weight 391.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Rizatriptan benzoate

References for Rizatriptan benzoate

References are publications that support the biological activity of the product.

Kaiser et al (2012) Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT1B/D agonist. J.Neurosci. 32 15439 PMID: 23115181

Street et al (1995) Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors. J.Med.Chem. 38 1799 PMID: 7752204

If you know of a relevant reference for Rizatriptan benzoate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT1B Receptor Agonists

Keywords: Rizatriptan benzoate, Rizatriptan benzoate supplier, selective, 5-HT, serotonin, 5-HT1D, 5-HT1B, receptors, agonists, Rizatriptan, benzoate, serotonergics, MK462, MK, 462, Receptors, 5136, Tocris Bioscience

Citations for Rizatriptan benzoate

Citations are publications that use Tocris products.

Currently there are no citations for Rizatriptan benzoate. Do you know of a great paper that uses Rizatriptan benzoate from Tocris? Please let us know.

Reviews for Rizatriptan benzoate

There are currently no reviews for this product. Be the first to review Rizatriptan benzoate and earn rewards!

Have you used Rizatriptan benzoate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Parkinson's Poster

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.