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Description: Potent 5-HT2 antagonist
Chemical Name: 6-[2-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
Purity: ≥98% (HPLC)
Citations (7)
Literature (1)

Biological Activity for Ritanserin

Ritanserin is a potent and long-acting 5-HT2 receptor antagonist (Ki = 0.39 nM). Anxiolytic in vivo.

Compound Libraries for Ritanserin

Ritanserin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ritanserin

M. Wt 477.57
Formula C27H25F2N3OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 87051-43-2
PubChem ID 5074
Smiles O=C1N3C(SC=C3)=NC(C)=C1CCN4CC/C(CC4)=C(C5=CC=C(F)C=C5)/C2=CC=C(F)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ritanserin

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 11.94 25
DMSO 47.76 100

Preparing Stock Solutions for Ritanserin

The following data is based on the product molecular weight 477.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.47 mL 20.94 mL
5 mM 0.42 mL 2.09 mL 4.19 mL
10 mM 0.21 mL 1.05 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets for Ritanserin

Certificate of Analysis / Product Datasheet
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References for Ritanserin

References are publications that support the biological activity of the product.

Janssen (1985) Pharmacology of potent and selective S2-serotonergic antagonists. J.Cardiovasc.Pharmacol. 7 S2 PMID: 2412048

Leysen et al (1985) Receptor-binding properties in vitro and in vivo of ritanserin. Mol.Pharmacol. 27 600 PMID: 2860558

Watanabe et al (1992) Syntheses and 5-HT2 antagonist activity of bicyclic 1,2,4-triazol-3(2H)-one and 1,3,5-triazine-2,4(3H)-dione derivatives. J.Med.Chem. 35 189 PMID: 1732528

If you know of a relevant reference for Ritanserin, please let us know.

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Keywords: Ritanserin, Ritanserin supplier, Potent, 5-HT2, antagonists, Non-Selective, Serotonin, Receptors, Non-selective, 1955, Tocris Bioscience

7 Citations for Ritanserin

Citations are publications that use Tocris products. Selected citations for Ritanserin include:

Bracha et al (2013) The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line. Physiol Behav 9 251 PMID: 24330646

Shimizu et al (2017) Brain serotoninergic nervous system is involved in bombesin-induced frequent urination through brain 5-HT7 receptors in rats. Br J Pharmacol 174 3072 PMID: 28675470

Alsene and Bakshi (2011) Pharmacological stimulation of locus coeruleus reveals a new antipsychotic-responsive pathway for deficient sensorimotor gating. Neuropsychopharmacology 36 1656 PMID: 21508929

Mondal et al (2013) Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons. PLoS One 8 e60365 PMID: 23565235

Do you know of a great paper that uses Ritanserin from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.