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Biological Activity for RIPA 56
RIPA 56 is a potent and metabolically stable receptor-interacting protein kinase 1 (RIPK1) inhibitor (EC50 = 13 nM). RIPA-56 shows no inhibition of RIP3 kinase at 10 μM. RIPA 56 blocks necroptosis and aging of the mouse male reproductive system. RIPA 56 reduces tumor necrosis factor α (TNFα)-induced mortality and multi-organ damage in a mouse model of systemic inflammatory response syndrome (SIRS). RIPA 56 is orally bioavailable.
Technical Data for RIPA 56
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RIPA 56
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for RIPA 56
The following data is based on the product molecular weight 221.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.52 mL||22.59 mL||45.19 mL|
|5 mM||0.9 mL||4.52 mL||9.04 mL|
|10 mM||0.45 mL||2.26 mL||4.52 mL|
|50 mM||0.09 mL||0.45 mL||0.9 mL|
References for RIPA 56
References are publications that support the biological activity of the product.
Li et al (2017) RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. Elife 6 e27692 PMID: 28807105
Ren et al (2017) Discovery of a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) for the treatment of systemic inflammatory response syndrome. J.Med.Chem. 60 972 PMID: 27992216
Zhuang et al (2019) Small-molecule inhibitors of necroptosis: current status and perspectives. J.Med.Chem. 63 1490 PMID: 31622096
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Citations for RIPA 56
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