RIPA 56

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Description: Potent and metabolically stable RIP1 kinase inhibitor
Chemical Name: N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for RIPA 56

RIPA 56 is a potent and metabolically stable receptor-interacting protein kinase 1 (RIPK1) inhibitor (EC50 = 13 nM). RIPA-56 shows no inhibition of RIP3 kinase at 10 μM. RIPA 56 blocks necroptosis and aging of the mouse male reproductive system. RIPA 56 reduces tumor necrosis factor α (TNFα)-induced mortality and multi-organ damage in a mouse model of systemic inflammatory response syndrome (SIRS). RIPA 56 is orally bioavailable.

Technical Data for RIPA 56

M. Wt 221.3
Formula C13H19NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1956370-21-0
PubChem ID 121439991
InChI Key AVYVHIKSFXVDBG-UHFFFAOYSA-N
Smiles O=C(N(O)CC=1C=CC=CC1)C(C)(C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RIPA 56

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.13 100
ethanol 22.13 100

Preparing Stock Solutions for RIPA 56

The following data is based on the product molecular weight 221.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.52 mL 22.59 mL 45.19 mL
5 mM 0.9 mL 4.52 mL 9.04 mL
10 mM 0.45 mL 2.26 mL 4.52 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

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References for RIPA 56

References are publications that support the biological activity of the product.

Li et al (2017) RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. Elife 6 e27692 PMID: 28807105

Ren et al (2017) Discovery of a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) for the treatment of systemic inflammatory response syndrome. J.Med.Chem. 60 972 PMID: 27992216

Zhuang et al (2019) Small-molecule inhibitors of necroptosis: current status and perspectives. J.Med.Chem. 63 1490 PMID: 31622096


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Citations for RIPA 56

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