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Cat.No. 4121 - Rifampicin | C43H58N4O12 | CAS No. 13292-46-1
Description: Pregnane X receptor agonist; antibiotic
Alternative Names: Rifampin
Chemical Name: 3-[[(4-Methyl-1-piperazinyl)imino]methyl]-rifamycin
Purity: ≥95% (HPLC)
Reviews (1)
Literature (2)

Biological Activity for Rifampicin

Rifampicin is an antibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR).

Technical Data for Rifampicin

M. Wt 822.94
Formula C43H58N4O12
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 13292-46-1
PubChem ID 5381226
Smiles CN(CC1)CCN1/N=C/C2=C(O)C3=C(C4=O)C5=C(C)C(O)=C3C(O)=C2NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@H]([C@H]([C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@]4(C)O5)O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rifampicin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 82.29 100

Preparing Stock Solutions for Rifampicin

The following data is based on the product molecular weight 822.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.22 mL 6.08 mL 12.15 mL
5 mM 0.24 mL 1.22 mL 2.43 mL
10 mM 0.12 mL 0.61 mL 1.22 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

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References for Rifampicin

References are publications that support the biological activity of the product.

Wehrli (1983) Rifampin: mechanisms of action and resistance. Rev.Infect.Dis. 5 S407 PMID: 6356275

Moore et al (2000) Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J.Biol.Chem. 275 15122 PMID: 10748001

Artsimovitch et al (2005) Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell 122 351 PMID: 16096056

Hu et al (2010) Pregnane X receptor is SUMOylated to repress the inflammatory response. J.Pharmacol.Exp.Ther. 335 342 PMID: 20719936

If you know of a relevant reference for Rifampicin, please let us know.

View Related Products by Product Action

View all Pregnane X Receptor Agonists

Keywords: Rifampicin, Rifampicin supplier, bacterial, RNA, polymerase, antibiotics, inhibitors, inhibits, pregnane, x, receptors, PXR, activators, Rifampin, Antibiotics, Pregnane, X, Receptor, DNA,, and, Protein, Synthesis, 4121, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Rifampin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Rifampicin

Citations are publications that use Tocris products.

Currently there are no citations for Rifampicin. Do you know of a great paper that uses Rifampicin from Tocris? Please let us know.

Reviews for Rifampicin

Average Rating: 5 (Based on 1 Review.)

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Rifampicin resisistance in E.coli cells was studied.
By Anonymous on 12/03/2018
Assay Type: In Vitro
Species: Human

In our lab rifampicin resisistance in E.coli cells was studied.To assess the level of antibiotic resistance, the minimum inhibitory concentration (MICs) of rifampicin in the non-mutated strain and mutated strain were compared.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors
Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.