Rifampicin

Pricing Availability Delivery Time Qty
Cat.No. 4121 - Rifampicin | C43H58N4O12 | CAS No. 13292-46-1
Description: Pregnane X receptor agonist; antibiotic
Alternative Names: Rifampin
Chemical Name: 3-[[(4-Methyl-1-piperazinyl)imino]methyl]-rifamycin
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR).

Technical Data

M. Wt 822.94
Formula C43H58N4O12
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 13292-46-1
PubChem ID 5381226
InChI Key FZYOVNIOYYPUPY-ZTWDQPHTSA-N
Smiles CN(CC3)CCN3/N=C/C2=C(O)C1=C(C5=O)C4=C(C)C(O)=C1C(O)=C2NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@H]([C@H]([C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@]5(C)O4)O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 82.29 100

Preparing Stock Solutions

The following data is based on the product molecular weight 822.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.22 mL 6.08 mL 12.15 mL
5 mM 0.24 mL 1.22 mL 2.43 mL
10 mM 0.12 mL 0.61 mL 1.22 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wehrli (1983) Rifampin: mechanisms of action and resistance. Rev.Infect.Dis. 5 S407 PMID: 6356275

Moore et al (2000) Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J.Biol.Chem. 275 15122 PMID: 10748001

Artsimovitch et al (2005) Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell 122 351 PMID: 16096056

Hu et al (2010) Pregnane X receptor is SUMOylated to repress the inflammatory response. J.Pharmacol.Exp.Ther. 335 342 PMID: 20719936


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View all Pregnane X Receptor Agonists

Keywords: bacterial RNA polymerase antibiotics inhibitors inhibits pregnane x receptors PXR activators Rifampin Pregnane X Receptor

Citations for Rifampicin

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Literature in this Area

Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

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  • Estrogen Receptors
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Retinoid Receptors

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.

Pathways for Rifampicin

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