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Cat.No. 3841 - RETF-4NA | Ac-Arg-Glu-Thr-Phe-4-Nitroanilide | CAS No. 1160928-63-1
Description: Selective chymase substrate

Biological Activity

Chymase substrate peptide that is cleaved more avidly by α2-macroglobulin-bound chymase than the free, unbound form. Displays selectivity over cathepsin G and chymotrypsin.

Technical Data

M. Wt 713.75
Formula C32H43N9O10
Sequence RETF

(Modifications: Arg-1 = N-terminal Ac, Phe-4 = 4-Nitroanilide)

Storage Store at -20°C
CAS Number 1160928-63-1
PubChem ID 90488886
Smiles C[C@@H](O)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NC1=CC=C(C=C1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in 20% acetonitrile / water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Raymond et al (2009) α2-macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generated activity. J.Immunol. 182 5770 PMID: 19380825

If you know of a relevant reference for RETF-4NA, please let us know.

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