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Resiquimod is a toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral.
Resiquimod is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 314.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.18 mL||15.9 mL||31.81 mL|
|5 mM||0.64 mL||3.18 mL||6.36 mL|
|10 mM||0.32 mL||1.59 mL||3.18 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References are publications that support the biological activity of the product.
Dockrell and Kinghorn (2001) Imiquimod and resiquimod as novel immunomodulators. J.Antimicrob.Chemother. 48 751 PMID: 11733457
Miyamoto et al (2012) R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts. Cytotechnology. 64 331 PMID: 22358541
Wagner et al (1999) Modulation of TH1 and Th2 cytokine production with the immune response modifiers, R-848 and imiq. Cell Immunol. 191 10 PMID: 9918682
Lee et al (2014) Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells. Arch.Pharm.Res. 37 1234 PMID: 24748512
If you know of a relevant reference for Resiquimod, please let us know.
Keywords: Resiquimod, Resiquimod supplier, proinflammatory, toll, like, receptors, ligands, agonists, TLR7, cytokines, interferons, interleukins, R848, R_848, myeloid-derived, suppressor, cells, MDSCs, tumor, microenvironment, R, 848, Toll-like, Receptors, Non-selective, Antivirals, 4536, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for Resiquimod. Do you know of a great paper that uses Resiquimod from Tocris? Please let us know.
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