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Description: Toll-like receptor 7 (TLR7) agonist
Alternative Names: R 848
Chemical Name: 1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
Purity: ≥98% (HPLC)
Citations (2)
Reviews (1)
Pathways (1)

Biological Activity for Resiquimod

Resiquimod is a toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral.

Compound Libraries for Resiquimod

Resiquimod is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Resiquimod

M. Wt 314.38
Formula C17H22N4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 144875-48-9
PubChem ID 159603
Smiles NC1=C3C(N(CC(C)(O)C)C(COCC)=N3)=C2C(C=CC=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Resiquimod

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.44 100
ethanol 15.72 50

Preparing Stock Solutions for Resiquimod

The following data is based on the product molecular weight 314.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.18 mL 15.9 mL 31.81 mL
5 mM 0.64 mL 3.18 mL 6.36 mL
10 mM 0.32 mL 1.59 mL 3.18 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets for Resiquimod

Certificate of Analysis / Product Datasheet
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References for Resiquimod

References are publications that support the biological activity of the product.

Dockrell and Kinghorn (2001) Imiquimod and resiquimod as novel immunomodulators. J.Antimicrob.Chemother. 48 751 PMID: 11733457

Miyamoto et al (2012) R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts. Cytotechnology. 64 331 PMID: 22358541

Wagner et al (1999) Modulation of TH1 and Th2 cytokine production with the immune response modifiers, R-848 and imiq. Cell Immunol. 191 10 PMID: 9918682

Lee et al (2014) Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells. Arch.Pharm.Res. 37 1234 PMID: 24748512

If you know of a relevant reference for Resiquimod, please let us know.

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Keywords: Resiquimod, Resiquimod supplier, proinflammatory, toll, like, receptors, ligands, agonists, TLR7, cytokines, interferons, interleukins, R848, R_848, myeloid-derived, suppressor, cells, MDSCs, tumor, microenvironment, R, 848, Toll-like, Receptors, Non-selective, Antivirals, 4536, Tocris Bioscience

2 Citations for Resiquimod

Citations are publications that use Tocris products. Selected citations for Resiquimod include:

Ming et al (2022) Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine. Cell Discov 8 10 PMID: 35102140

Yumi et al (2022) Imprime PGG Enhances Anti-Tumor Effects of Tumor-Targeting, Anti-Angiogenic, and Immune Checkpoint Inhibitor Antibodies. Front Oncol 12 869078 PMID: 35692755

Do you know of a great paper that uses Resiquimod from Tocris? Please let us know.

Reviews for Resiquimod

Average Rating: 5 (Based on 1 Review.)

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Good, stores well.
By Scott Scarneo on 02/06/2019
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: BMDM

Worked well for macrophages and got the desired result by TNF production.

review image

Pathways for Resiquimod

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.