Rauwolscine hydrochloride

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Cat.No. 0891 - Rauwolscine hydrochloride | C21H26N2O3.HCl | CAS No. 6211-32-1
Description: α2 antagonist
Alternative Names: α-Yohimbine hydrochloride, Corynanthidine
Chemical Name: 17α-Hydroxy-20α-yohimban-16β-carboxylic acid,methyl ester hydrochloride
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Standard α2-adrenergic antagonist (Ki values are 3.5, 4.6, and 0.6 nM at cloned human α2A, α2B, and α2C-adrenoceptors respectively). Partial agonist at 5-HT1A receptors.

Available as part of the α2-Adrenoceptor Tocriset™. Diastereomer also avilable.

Compound Libraries

Rauwolscine hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 390.91
Formula C21H26N2O3.HCl
Storage Store at RT
Purity ≥95% (HPLC)
CAS Number 6211-32-1
PubChem ID 197067
InChI Key PIPZGJSEDRMUAW-ZKKXXTDSSA-N
Smiles [H][C@]12C4=C(C(C=CC=C5)=C5N4)CCN1C[C@]3([H])[C@]([C@H]([C@](OC)=O)[C@@H](O)CC3)([H])C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 5 mM in water with gentle warming and to 25 mM in DMSO with gentle warming

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Arthur et al (1993) Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors. Biochem.Pharmacol. 45 2337 PMID: 8517875

Hieble et al (1995) β- and γ-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428

Uhlen et al (1998) [3H]RS79948-197 binding to human, rat, guinea pig and pig α2A-, α2B-, and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 343 93 PMID: 9551719


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2 Citations for Rauwolscine hydrochloride

Citations are publications that use Tocris products. Selected citations for Rauwolscine hydrochloride include:

Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049 PMID: 17075569

Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. J Neurosci 24 7745 PMID: 15342742


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Literature in this Area

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