Rauwolscine hydrochloride
Biological Activity
Standard α2-adrenergic antagonist (Ki values are 3.5, 4.6, and 0.6 nM at cloned human α2A, α2B, and α2C-adrenoceptors respectively). Partial agonist at 5-HT1A receptors.
Available as part of the α2-Adrenoceptor Tocriset™. Diastereomer also avilable.
Compound Libraries
Rauwolscine hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 390.91 |
| Formula | C21H26N2O3.HCl |
| Storage | Store at RT |
| Purity | ≥95% (HPLC) |
| CAS Number | 6211-32-1 |
| PubChem ID | 197067 |
| InChI Key | PIPZGJSEDRMUAW-ZKKXXTDSSA-N |
| Smiles | [H][C@]12C4=C(C(C=CC=C5)=C5N4)CCN1C[C@]3([H])[C@]([C@H]([C@](OC)=O)[C@@H](O)CC3)([H])C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 5 mM in water with gentle warming and to 25 mM in DMSO with gentle warming |
Product Datasheets
References
References are publications that support the biological activity of the product.
Arthur et al (1993) Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors. Biochem.Pharmacol. 45 2337 PMID: 8517875
Hieble et al (1995) β- and γ-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428
Uhlen et al (1998) [3H]RS79948-197 binding to human, rat, guinea pig and pig α2A-, α2B-, and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 343 93 PMID: 9551719
If you know of a relevant reference for Rauwolscine hydrochloride, please let us know.
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2 Citations for Rauwolscine hydrochloride
Citations are publications that use Tocris products. Selected citations for Rauwolscine hydrochloride include:
Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049 PMID: 17075569
Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. J Neurosci 24 7745 PMID: 15342742
Do you know of a great paper that uses Rauwolscine hydrochloride from Tocris? Please let us know.
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