Ranolazine dihydrochloride

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Cat.No. 3118 - Ranolazine dihydrochloride | C24H33N3O4.2HCl | CAS No. 95635-56-6
Description: Antianginal, activates pyruvate dehydrogenase
Alternative Names: RS 43285
Chemical Name: N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late INa and IKr currents.

Compound Libraries

Ranolazine dihydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 500.46
Formula C24H33N3O4.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 95635-56-6
PubChem ID 71279
InChI Key RJNSNFZXAZXOFX-UHFFFAOYSA-N
Smiles COC1=CC=CC=C1OCC(CN2CCN(CC(NC3=C(C)C=CC=C3C)=O)CC2)O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.05 100
water 50.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 500.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.98 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Zacharowski et al (2001) Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur.J.Pharmacol. 418 105 PMID: 11334871

Shryock and Belardinelli (2008) Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium. Br.J.Pharmacol. 153 1128 PMID: 18071302

Wang et al (2008) Antitorsadogenic effects of (+/-)-N-(2,6-dimethyl-phenyl)-4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J.Pharmacol.Exp.Ther. 325 875 PMID: 18322148


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Citations for Ranolazine dihydrochloride

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