Ralfinamide mesylate

Pricing Availability Delivery Time Qty
Cat.No. 4029 - Ralfinamide mesylate | C17H19FN2O2.CH3SO3H | CAS No. 202825-45-4
Description: Na+ channel blocker
Chemical Name: (2S)-2-[[[4-[(2-Fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide methanesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Sodium channel blocker. Suppresses tetrodotoxin (TTX)-resistant Na+ currents approximately twice as selectively as TTX-sensitive currents. Antinociceptive; displays analgesic effects in animal models of inflammatory and neuropathic pain.

Compound Libraries

Ralfinamide mesylate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 398.45
Formula C17H19FN2O2.CH3SO3H
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 202825-45-4
PubChem ID 23661379
InChI Key CHQVNINIGBRKGZ-YDALLXLXSA-N
Smiles FC(C=CC=C2)=C2COC1=CC=C(CN[C@@H](C)C(N)=O)C=C1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.84 100
water 9.96 25

Preparing Stock Solutions

The following data is based on the product molecular weight 398.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.1 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Veneroni et al (2003) Anti-allodynic effect of NW-1029, a novel Na+ channel blocker, in experimental animal models of inflammatory and neuropathic pain. Pain 102 17 PMID: 12620593

Yamane et al (2007) Effects of ralfinamide, a Na+ channel blocker, on firing properties of nociceptive dorsal root ganglion neurons of adult rats. Exp.Neurol. 208 63 PMID: 17707373

Zhang et al (2008) Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain 139 293 PMID: 18583049


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Keywords: Ralfinamide mesylate, supplier, Ralfinamide, sodium, Na+, blockers, channels, NaV, tetrodotoxin, TTXr, TTXs, Voltage-gated, Sodium, Channels, Tocris Bioscience

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