rac BHFF

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Description: Potent and selective postitive allosteric modulator of GABAB receptors
Chemical Name: 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for rac BHFF

rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity in vivo and is orally active.

Compound Libraries for rac BHFF

rac BHFF is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for rac BHFF

M. Wt 330.34
Formula C17H21F3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 123557-91-5
PubChem ID 4332683
InChI Key RVNOANDLZIIFHB-UHFFFAOYSA-N
Smiles CC(C)(C)C1=C2C(C(O)(C(F)(F)F)C(O2)=O)=CC(C(C)(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for rac BHFF

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.03 100
ethanol 33.03 100

Preparing Stock Solutions for rac BHFF

The following data is based on the product molecular weight 330.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.14 mL 30.27 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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References for rac BHFF

References are publications that support the biological activity of the product.

Malherbe et al (2008) Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br.J.Pharmacol. 154 797 PMID: 18536733

Koek et al (2013) Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse. J.Pharmacol.Exp.Ther. 344 553 PMID: 23275067


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Keywords: rac BHFF, rac BHFF supplier, Potent, selective, GABAB, positive, allosteric, modulators, Receptors, 3313, Tocris Bioscience

1 Citation for rac BHFF

Citations are publications that use Tocris products. Selected citations for rac BHFF include:

Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Clin Exp Dermatol 5 10468 PMID: 26020477


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Reviews for rac BHFF

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.