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Biological Activity for rac BHFF
rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity in vivo and is orally active.
Compound Libraries for rac BHFF
Technical Data for rac BHFF
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for rac BHFF
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for rac BHFF
The following data is based on the product molecular weight 330.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.03 mL||15.14 mL||30.27 mL|
|5 mM||0.61 mL||3.03 mL||6.05 mL|
|10 mM||0.3 mL||1.51 mL||3.03 mL|
|50 mM||0.06 mL||0.3 mL||0.61 mL|
References for rac BHFF
References are publications that support the biological activity of the product.
Malherbe et al (2008) Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br.J.Pharmacol. 154 797 PMID: 18536733
Koek et al (2013) Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse. J.Pharmacol.Exp.Ther. 344 553 PMID: 23275067
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Keywords: rac BHFF, rac BHFF supplier, Potent, selective, GABAB, positive, allosteric, modulators, Receptors, 3313, Tocris Bioscience
1 Citation for rac BHFF
Citations are publications that use Tocris products. Selected citations for rac BHFF include:
Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Clin Exp Dermatol 5 10468 PMID: 26020477
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.