rac BHFF

Pricing Availability Delivery Time Qty
Cat.No. 3313 - rac BHFF | C17H21F3O3 | CAS No. 123557-91-5
Description: Potent, selective GABAB positive allosteric modulator
Chemical Name: 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective GABAB receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity in vivo and is orally active.

Compound Libraries

rac BHFF is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 330.34
Formula C17H21F3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 123557-91-5
PubChem ID 4332683
InChI Key RVNOANDLZIIFHB-UHFFFAOYSA-N
Smiles CC(C)(C)C1=C2C(C(O)(C(F)(F)F)C(O2)=O)=CC(C(C)(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.03 100
ethanol 33.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 330.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.14 mL 30.27 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Malherbe et al (2008) Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br.J.Pharmacol. 154 797 PMID: 18536733

Koek et al (2013) Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse. J.Pharmacol.Exp.Ther. 344 553 PMID: 23275067


If you know of a relevant reference for rac BHFF, please let us know.

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Keywords: Potent selective GABAB positive allosteric modulators Receptors GABAB Receptors

1 Citation for rac BHFF

Citations are publications that use Tocris products. Selected citations for rac BHFF include:

Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Clin Exp Dermatol 5 10468 PMID: 26020477


Do you know of a great paper that uses rac BHFF from Tocris? If so please let us know.

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Pathways for rac BHFF

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