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Biological Activity for RA 839
RA 839 is a Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.
Compound Libraries for RA 839
Technical Data for RA 839
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RA 839
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for RA 839
The following data is based on the product molecular weight 452.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.21 mL||11.05 mL||22.1 mL|
|5 mM||0.44 mL||2.21 mL||4.42 mL|
|10 mM||0.22 mL||1.1 mL||2.21 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References for RA 839
References are publications that support the biological activity of the product.
Winkel et al (2015) Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. J.Biol.Chem. 290 28446 PMID: 26459563
If you know of a relevant reference for RA 839, please let us know.
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Keywords: RA 839, RA 839 supplier, RA839, Nrf2, activators, activates, NFE2L2, erythroid-derived, nuclear, factors, Keap1, interations, inhibitors, inhibits, inducible, nitric, oxide, synthases, oxides, anti-inflammatory, 5707, Tocris Bioscience
Citations for RA 839
Citations are publications that use Tocris products.
Currently there are no citations for RA 839. Do you know of a great paper that uses RA 839 from Tocris? Please let us know.
Reviews for RA 839
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Literature in this Area
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