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RA 839 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.
RA 839 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 452.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.21 mL||11.05 mL||22.1 mL|
|5 mM||0.44 mL||2.21 mL||4.42 mL|
|10 mM||0.22 mL||1.1 mL||2.21 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the biological activity of the product.
Winkel et al (2015) Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. J.Biol.Chem. 290 28446 PMID: 26459563
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Keywords: RA 839, RA 839 supplier, RA839, Nrf2, activators, activates, NFE2L2, erythroid-derived, nuclear, factors, Keap1, interations, inhibitors, inhibits, inducible, nitric, oxide, synthases, oxides, anti-inflammatory, 5707, Tocris Bioscience
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