RA 839

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Description: Nrf2 activator; inhibits Nrf2/Keap1 interaction
Chemical Name: (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)

Biological Activity for RA 839

RA 839 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.

Compound Libraries for RA 839

RA 839 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RA 839

M. Wt 452.57
Formula C25H28N2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1832713-02-6
PubChem ID 91971266
Smiles CC1=C(C)C=C(C)C(C)=C1S(=O)(NC2=C(C=CC=C3)C3=C(N4C[C@@H](C(O)=O)CC4)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RA 839

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.26 100

Preparing Stock Solutions for RA 839

The following data is based on the product molecular weight 452.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for RA 839

References are publications that support the biological activity of the product.

Winkel et al (2015) Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. J.Biol.Chem. 290 28446 PMID: 26459563

If you know of a relevant reference for RA 839, please let us know.

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Keywords: RA 839, RA 839 supplier, RA839, Nrf2, activators, activates, NFE2L2, erythroid-derived, nuclear, factors, Keap1, interations, inhibitors, inhibits, inducible, nitric, oxide, synthases, oxides, anti-inflammatory, 5707, Tocris Bioscience

2 Citations for RA 839

Citations are publications that use Tocris products. Selected citations for RA 839 include:

Rakesh et al (2020) Progressive Rotavirus Infection Downregulates Redox-Sensitive Transcription Factor Nrf2 and Nrf2-Driven Transcription Units. Oxid Med Cell Longev 2020 7289120 PMID: 32322337

Vladimir et al (2021) A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy. Redox Biol 48 102186 PMID: 34801863

Do you know of a great paper that uses RA 839 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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