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RA 839

Cat. No. 5707 Submit a Review Datasheet / COA / SDS
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Description: Nrf2 activator; inhibits Nrf2/Keap1 interaction
Chemical Name: (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for RA 839

RA 839 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.

Compound Libraries for RA 839

RA 839 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RA 839

M. Wt 452.57
Formula C25H28N2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1832713-02-6
PubChem ID 91971266
InChI Key BVYWIQHJXAEJOD-IBGZPJMESA-N
Smiles CC1=C(C)C=C(C)C(C)=C1S(=O)(NC2=C(C=CC=C3)C3=C(N4C[C@@H](C(O)=O)CC4)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RA 839

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.26 100

Preparing Stock Solutions for RA 839

The following data is based on the product molecular weight 452.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for RA 839

References are publications that support the biological activity of the product.

Winkel et al (2015) Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. J.Biol.Chem. 290 28446 PMID: 26459563

If you know of a relevant reference for RA 839, please let us know.

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Citations for RA 839

Citations are publications that use Tocris products.

Currently there are no citations for RA 839. Do you know of a great paper that uses RA 839 from Tocris? Please let us know.

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