Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||4.53||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 452.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.21 mL||11.05 mL||22.1 mL|
|5 mM||0.44 mL||2.21 mL||4.42 mL|
|10 mM||0.22 mL||1.1 mL||2.21 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Winkel et al (2015) Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. J.Biol.Chem. 290 28446 PMID: 26459563
If you know of a relevant reference for RA 839, please let us know.
View Related Products by Product Action
Keywords: RA 839, supplier, RA839, Nrf2, activators, activates, NFE2L2, erythroid-derived, nuclear, factors, Keap1, interations, inhibitors, inhibits, inducible, nitric, oxide, synthases, nitric, oxides, anti-inflammatory, Nrf2, Nrf2, Tocris Bioscience
Citations for RA 839
Citations are publications that use Tocris products.
Currently there are no citations for RA 839. Do you know of a great paper that uses RA 839 from Tocris? If so please let us know.