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Less active enantiomer of the PDE4 inhibitor Rolipram.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 275.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.63 mL||18.16 mL||36.32 mL|
|5 mM||0.73 mL||3.63 mL||7.26 mL|
|10 mM||0.36 mL||1.82 mL||3.63 mL|
|50 mM||0.07 mL||0.36 mL||0.73 mL|
References are publications that support the biological activity of the product.
Ohsawa et al (1998) Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn.J.Pharmacol. 77 147 PMID: 9681571
Owens et al (1997) Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells. Biochem.J. 326 53 PMID: 9337850
Schneider et al (1986) Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol. 127 105 PMID: 3019721
If you know of a relevant reference for (S)-(+)-Rolipram, please let us know.
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Keywords: (S)-(+)-Rolipram, (S)-(+)-Rolipram supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, 1350, Tocris Bioscience
4 Citations for (S)-(+)-Rolipram
Citations are publications that use Tocris products. Selected citations for (S)-(+)-Rolipram include:
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333
Meyer et al (2012) Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization. Int J Nanomedicine 7 2449 PMID: 22654517
Boomkamp et al (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. J Biol Chem 171 2385 PMID: 24467222
Brancaleone et al (2014) Annexin A1 mediates hydrogen sulfide properties in the control of inflammation. J Pharmacol Exp Ther 351 96 PMID: 25077524
Do you know of a great paper that uses (S)-(+)-Rolipram from Tocris? Please let us know.
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Literature in this Area
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