(R)-Modafinil

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Cat.No. 6131 - (R)-Modafinil | C15H15NO2S | CAS No. 112111-43-0
Description: Dopamine uptake inhibitor
Alternative Names: armodafinil
Chemical Name: (-)-2R-[(Diphenylmethyl)sulfinyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Dopamine uptake inhibitor (IC50 = 4 μM). Increases extracellular dopamine (DA) levels in the nucleus accumbens and substitutes for cocaine in discrimination tests in mice.

Technical Data

M. Wt 273.35
Formula C15H15NO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 112111-43-0
PubChem ID 9690109
InChI Key YFGHCGITMMYXAQ-LJQANCHMSA-N
Smiles O=[S@](CC(N)=O)C(C1=CC=CC=C1)C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 5.47 20
DMSO 27.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 273.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.66 mL 18.29 mL 36.58 mL
5 mM 0.73 mL 3.66 mL 7.32 mL
10 mM 0.37 mL 1.83 mL 3.66 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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References

References are publications that support the biological activity of the product.

Loland et al (2012) R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. Biol.Psychiatry 72 405 PMID: 22537794


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Citations for (R)-Modafinil

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