Pricing Availability   Qty
Cat.No. 6131 - (R)-Modafinil | C15H15NO2S | CAS No. 112111-43-0
Description: Dopamine uptake inhibitor
Alternative Names: armodafinil
Chemical Name: (-)-2R-[(Diphenylmethyl)sulfinyl]acetamide
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for (R)-Modafinil

(R)-Modafinil is a dopamine uptake inhibitor (IC50 = 4 μM). Increases extracellular dopamine (DA) levels in the nucleus accumbens and substitutes for cocaine in discrimination tests in mice.

Technical Data for (R)-Modafinil

M. Wt 273.35
Formula C15H15NO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 112111-43-0
PubChem ID 9690109
Smiles O=[S@](CC(N)=O)C(C1=CC=CC=C1)C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-Modafinil

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.34 100
ethanol 5.47 20

Preparing Stock Solutions for (R)-Modafinil

The following data is based on the product molecular weight 273.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.66 mL 18.29 mL 36.58 mL
5 mM 0.73 mL 3.66 mL 7.32 mL
10 mM 0.37 mL 1.83 mL 3.66 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for (R)-Modafinil

References for (R)-Modafinil

References are publications that support the biological activity of the product.

Loland et al (2012) R-modafinil (armodafinil): a unique DA uptake inhibitor and potential medication for psychostimulant abuse. Biol.Psychiatry 72 405 PMID: 22537794

If you know of a relevant reference for (R)-Modafinil, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Dopamine Transporter Inhibitors

Keywords: (R)-Modafinil, (R)-Modafinil supplier, dopamine, transporters, reuptake, inhibitors, inhibits, DAT, R-enantiomer, cocaine, discrimination, armodafinil, Dopamine, Transporters, 6131, Tocris Bioscience

Citations for (R)-Modafinil

Citations are publications that use Tocris products.

Currently there are no citations for (R)-Modafinil. Do you know of a great paper that uses (R)-Modafinil from Tocris? Please let us know.

Reviews for (R)-Modafinil

There are currently no reviews for this product. Be the first to review (R)-Modafinil and earn rewards!

Have you used (R)-Modafinil?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.


Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.


Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.