(R)-Citalopram oxalate

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Description: Enantiomer of escitalopram oxalate (Cat. No. 1427)
Chemical Name: (-)-(R)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile oxalate
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for (R)-Citalopram oxalate

(R)-Citalopram oxalate is an enantiomer of escitalopram oxalate. Postulated to allosterically modulate the affinity of the S-enantiomer.

Racemate and S-enantiomer also available.

Technical Data for (R)-Citalopram oxalate

M. Wt 414.43
Formula C20H21FN2O.C2H2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 219861-53-7
PubChem ID 45038690
Smiles FC(C=C3)=CC=C3[C@@]1(CCCN(C)C)OCC2=C1C=CC(C#N)=C2.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-Citalopram oxalate

Solvent Max Conc. mg/mL Max Conc. mM
water 20.72 50
DMSO 41.44 100

Preparing Stock Solutions for (R)-Citalopram oxalate

The following data is based on the product molecular weight 414.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.06 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for (R)-Citalopram oxalate

References for (R)-Citalopram oxalate

References are publications that support the biological activity of the product.

Jacquot et al (2007) Escitalopram and citalopram: the unexpected role of the R-enantiomer. Encephale 33 179 PMID: 17675913

Sánchez et al (2006) The pharmacology of cital. enantiomers: the antagonism by R-citalopram on the effect of S-citalopram. Basic & Clinical Pharmacology & Toxicology 99 91 PMID: 16918708

If you know of a relevant reference for (R)-Citalopram oxalate, please let us know.

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Keywords: (R)-Citalopram oxalate, (R)-Citalopram oxalate supplier, Enantiomers, escitalopram, oxalate, 5-HT, reuptake, modulators, allosteric, SERT, 5-hydroxytryptamine, monoamine, neurotransmitters, citalopram, depression, Transporters, 5763, Tocris Bioscience

1 Citation for (R)-Citalopram oxalate

Citations are publications that use Tocris products. Selected citations for (R)-Citalopram oxalate include:

Henry A et al (2020) Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell 183 1986-2002.e26 PMID: 33333022

Do you know of a great paper that uses (R)-Citalopram oxalate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.