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Submit Review(R)-(+)-8-Hydroxy-DPAT hydrobromide
Description: Selective 5-HT1A agonist; enantiomer of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529)
Chemical Name: (2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide
Purity: ≥98% (HPLC)
Biological Activity for (R)-(+)-8-Hydroxy-DPAT hydrobromide
(R)-(+)-8-Hydroxy-DPAT hydrobromide is a full 5-HT1A serotonin receptor agonist. Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. More active enantiomer of 8-Hydroxy-DPAT hydrobromide.
Racemate and 7-Hydroxy Isomer also available.
Technical Data for (R)-(+)-8-Hydroxy-DPAT hydrobromide
| M. Wt | 328.29 |
| Formula | C16H25NO.HBr |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 78095-19-9 |
| PubChem ID | 11957570 |
| InChI Key | BATPBOZTBNNDLN-PFEQFJNWSA-N |
| Smiles | Br.CCCN(CCC)[C@@H]1CCC2=CC=CC(O)=C2C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (R)-(+)-8-Hydroxy-DPAT hydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 24.62 | 75 | |
| DMSO | 24.62 | 75 |
Preparing Stock Solutions for (R)-(+)-8-Hydroxy-DPAT hydrobromide
The following data is based on the product molecular weight 328.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 4.06 mL | 20.31 mL | 40.61 mL |
| 3.75 mM | 0.81 mL | 4.06 mL | 8.12 mL |
| 7.5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 37.5 mM | 0.08 mL | 0.41 mL | 0.81 mL |
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Product Datasheets for (R)-(+)-8-Hydroxy-DPAT hydrobromide
References for (R)-(+)-8-Hydroxy-DPAT hydrobromide
References are publications that support the biological activity of the product.
Bjork et al (1989) Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain. J.Med.Chem. 32 779 PMID: 2522991
Corrfield et al (1991) Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogues at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Mol.Pharmacol. 39 780 PMID: 1828859
Yoshitake and Kehr (2004) Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 74 2865 PMID: 15050424
If you know of a relevant reference for (R)-(+)-8-Hydroxy-DPAT hydrobromide, please let us know.
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Keywords: (R)-(+)-8-Hydroxy-DPAT hydrobromide, (R)-(+)-8-Hydroxy-DPAT hydrobromide supplier, Selective, 5-HT1A, agonists, active, enantiomer, Serotonin, Receptors, 1080, Tocris Bioscience
4 Citations for (R)-(+)-8-Hydroxy-DPAT hydrobromide
Citations are publications that use Tocris products. Selected citations for (R)-(+)-8-Hydroxy-DPAT hydrobromide include:
Rossi et al (2008) Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by cital. and escital. Eur J Pharmacol 583 103 PMID: 18289523
Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. Psychopharmacology (Berl) 11 e0154932 PMID: 27183222
Wierońska et al (2015) The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies. Oncoscience 232 259 PMID: 25012236
Sadiq et al (2019) 5-HT1A Receptor Function Makes Wound Healing a Happier Process. Front Pharmacol 9 1406 PMID: 30618734
Do you know of a great paper that uses (R)-(+)-8-Hydroxy-DPAT hydrobromide from Tocris? Please let us know.
Reviews for (R)-(+)-8-Hydroxy-DPAT hydrobromide
Average Rating: 5 (Based on 1 Review.)
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The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound.
By
Anonymous on 02/01/2020
Assay Type: In Vitro
Species: Other
Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience
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