PYZD 4409

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Cat.No. 4994 - PYZD 4409 | C14H7ClFN3O5 | CAS No. 423148-78-1
Description: Ubiquitin-activating enzyme (E1) inhibitor
Chemical Name: 1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Ubiquitin-activating enzyme (E1) inhibitor. Blocks degradation of p53 and cyclin D3. Inhibits NF-κB activation and induces cell death associated with ER stress. Displays antitumor effects in a mouse model of leukemia.

Technical Data

M. Wt 351.67
Formula C14H7ClFN3O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 423148-78-1
PubChem ID 60111983
InChI Key MSYMKEYWUWVZQY-TWGQIWQCSA-N
Smiles FC(C=C3)=C(Cl)C=C3N(C(/C1=C\C2=CC=C([N+]([O-])=O)O2)=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.17 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.22 mL 28.44 mL
5 mM 0.57 mL 2.84 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Xu et al (2010) The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood 115 2251 PMID: 20075161


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Keywords: PYZD4409 ubiquitin-activating enzyme E1 inhibitors inhibits ubiquitylation ubiquitin Ubiquitin-activating Enzyme E1

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Pathways for PYZD 4409

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