PYZD 4409

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Cat.No. 4994 - PYZD 4409 | C14H7ClFN3O5 | CAS No. 423148-78-1
Description: Ubiquitin-activating enzyme (E1) inhibitor
Chemical Name: 1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity

Ubiquitin-activating enzyme (E1) inhibitor. Blocks degradation of p53 and cyclin D3. Inhibits NF-κB activation and induces cell death associated with ER stress. Displays antitumor effects in a mouse model of leukemia.

Technical Data

M. Wt 351.67
Formula C14H7ClFN3O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 423148-78-1
PubChem ID 60111983
Smiles FC(C=C3)=C(Cl)C=C3N(C(/C1=C\C2=CC=C([N+]([O-])=O)O2)=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.17 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.22 mL 28.44 mL
5 mM 0.57 mL 2.84 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References are publications that support the biological activity of the product.

Xu et al (2010) The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood 115 2251 PMID: 20075161

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Citations for PYZD 4409

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Literature in this Area

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