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Biological Activity for PTC 209
PTC 209 is a Bmi-1 inhibitor (IC50 ~ 0.5 μM); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors in vivo.
Technical Data for PTC 209
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PTC 209
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PTC 209
The following data is based on the product molecular weight 495.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.02 mL||10.1 mL||20.19 mL|
|5 mM||0.4 mL||2.02 mL||4.04 mL|
|10 mM||0.2 mL||1.01 mL||2.02 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References for PTC 209
References are publications that support the biological activity of the product.
Kreso et al (2014) Self-renewal as a therapeutic target in human colorectal cancer. Nat.Med. 20 29 PMID: 24292392
If you know of a relevant reference for PTC 209, please let us know.
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Keywords: PTC 209, PTC 209 supplier, PTC209, Bmi-1, inhibitors, inhibits, colorectal, cancer-initiating, cell, CIC, growth, polycomb, repressive, complex, 1, PRC1, B, lymphoma, Mo-MLV, insertion, region, homolog, Ubiquitin, E3, Ligases, 5191, Tocris Bioscience
Citations for PTC 209
Citations are publications that use Tocris products.
Currently there are no citations for PTC 209. Do you know of a great paper that uses PTC 209 from Tocris? Please let us know.
Reviews for PTC 209
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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