PSB 0474

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Cat.No. 2715 - PSB 0474 | C17H18N2Na2O13P2 | CAS No. 917567-60-3
Description: Potent and selective P2Y6 agonist
Alternative Names: 3-Phenacyl UDP disodium salt
Chemical Name: 3-(2-Oxo-2-phenylethyl)-uridine-5'-diphosphate disodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Potent and selective P2Y6 receptor agonist (EC50 values are 70, > 1000 and > 10000 nM for P2Y6, P2Y2 and P2Y4 receptors respectively). Induces contractions of rat isolated intrapulmonary arteries in vitro.

Technical Data

M. Wt 566.26
Formula C17H18N2Na2O13P2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 917567-60-3
PubChem ID 54591398
InChI Key LEICCBKKYICWFH-BWBFMJMBSA-L
Smiles [Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP(O)([O-])=O)N1C=CC(=O)N(CC(=O)C2=CC=CC=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in water (supplied pre-dissolved at a concentration of 10mM)

Preparing Stock Solutions

The following data is based on the product molecular weight 566.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.83 mL 17.66 mL
5 mM 0.35 mL 1.77 mL 3.53 mL
10 mM 0.18 mL 0.88 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

El-Tayeb et al (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors. J.Med.Chem. 49 7076 PMID: 17125260

Mitchell et al (2012) Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands. J.Pharmacol.Exp.Ther. 343 755 PMID: 22991416


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Keywords: PSB 0474, supplier, Potent, selective, P2Y6, agonists, Receptors, Purinergic, purinoceptors, PSB0474, 3-Phenacyl, UDP, disodium, salt, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience

4 Citations for PSB 0474

Citations are publications that use Tocris products. Selected citations for PSB 0474 include:

Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Exp Eye Res 9 31 PMID: 22825617

Kataoka et al (2011) Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways. Purinergic Signal 7 403 PMID: 21567128

Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29 PMID: 24886406

Quintas et al (2014) Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis. J Neuroinflammation 11 141 PMID: 25178395


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