Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMRS 2957 triethylammonium salt
Description: Potent and selective P2Y6 agonist
Chemical Name: P1-[5'(N4-Methoxycytidyl)]-P3-(5'-uridyl)-triphosphate tri(triethylammonium) salt
Purity: ≥99% (HPLC)
Biological Activity for MRS 2957 triethylammonium salt
MRS 2957 triethylammonium salt is a potent P2Y6 agonist (EC50 = 12 nM). Displays 14- and 66-fold selectivity against P2Y2 and P2Y4 receptors respectively.
Technical Data for MRS 2957 triethylammonium salt
| M. Wt | 1042.94 |
| Formula | C19H28N5O20P3.3(C2H5)3N |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| PubChem ID | 90488923 |
| InChI Key | UCQYWKBGVXRIQK-BJFMRLMLSA-N |
| Smiles | O[C@@H]1[C@@H](N2C(NC(C=C2)=O)=O)O[C@@H](COP(OP(OP(OC[C@H]3O[C@@H](N4C(NC(C=C4)=NOC)=O)[C@H](O)[C@@H]3O)([O-])=O)([O-])=O)([O-])=O)[C@@H]1O.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MRS 2957 triethylammonium salt
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Product Datasheets for MRS 2957 triethylammonium salt
References for MRS 2957 triethylammonium salt
References are publications that support the biological activity of the product.
Maruoka et al (2010) Pyrimidine ribonucleotides with enhanced selectivity as P2Y6 receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate γ-ester modifications. J.Med.Chem. 53 4488 PMID: 20446735
If you know of a relevant reference for MRS 2957 triethylammonium salt, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MRS 2957 triethylammonium salt, MRS 2957 triethylammonium salt supplier, MRS2957, triethylammonium, salt, potent, selective, purinergics, purines, purinoceptors, p2y6, agonists, 1228271-30-4, Purinergic, P2Y, Receptors, 4260, Tocris Bioscience
1 Citation for MRS 2957 triethylammonium salt
Citations are publications that use Tocris products. Selected citations for MRS 2957 triethylammonium salt include:
Balasubramanian et al (2014) Enhancement of glucose uptake in mouse skeletal muscle cells and adipocytes by P2Y6 receptor agonists. Nat Methods 9 e116203 PMID: 25549240
Do you know of a great paper that uses MRS 2957 triethylammonium salt from Tocris? Please let us know.
Reviews for MRS 2957 triethylammonium salt
There are currently no reviews for this product. Be the first to review MRS 2957 triethylammonium salt and earn rewards!
Have you used MRS 2957 triethylammonium salt?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.