MRS 2957 triethylammonium salt

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Cat.No. 4260 - MRS 2957 triethylammonium salt | C19H28N5O20P3.3(C2H5)3N | CAS No. 1228271-30-4
Description: Potent and selective P2Y6 agonist
Chemical Name: P1-[5'(N4-Methoxycytidyl)]-P3-(5'-uridyl)-triphosphate tri(triethylammonium) salt
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent P2Y6 agonist (EC50 = 12 nM). Displays 14- and 66-fold selectivity against P2Y2 and P2Y4 receptors respectively.

Technical Data

M. Wt 1042.94
Formula C19H28N5O20P3.3(C2H5)3N
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1228271-30-4
PubChem ID 90488923
InChI Key UCQYWKBGVXRIQK-BJFMRLMLSA-N
Smiles O[C@@H]1[C@@H](N2C(NC(C=C2)=O)=O)O[C@@H](COP(OP(OP(OC[C@H]3O[C@@H](N4C(NC(C=C4)=NOC)=O)[C@H](O)[C@@H]3O)([O-])=O)([O-])=O)([O-])=O)[C@@H]1O.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in water (supplied pre-dissolved at a concentration of 10mM)

Preparing Stock Solutions

The following data is based on the product molecular weight 1042.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.96 mL 4.79 mL 9.59 mL
5 mM 0.19 mL 0.96 mL 1.92 mL
10 mM 0.1 mL 0.48 mL 0.96 mL
50 mM 0.02 mL 0.1 mL 0.19 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Maruoka et al (2010) Pyrimidine ribonucleotides with enhanced selectivity as P2Y6 receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate γ-ester modifications. J.Med.Chem. 53 4488 PMID: 20446735


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1 Citation for MRS 2957 triethylammonium salt

Citations are publications that use Tocris products. Selected citations for MRS 2957 triethylammonium salt include:

Balasubramanian et al (2014) Enhancement of glucose uptake in mouse skeletal muscle cells and adipocytes by P2Y6 receptor agonists. Nat Methods 9 e116203 PMID: 25549240


Do you know of a great paper that uses MRS 2957 triethylammonium salt from Tocris? If so please let us know.

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