PS 48

Discontinued Product

Unfortunately PS 48 (Cat. No. 4087) has been withdrawn from sale for commercial reasons.
Cat.No. 4087 - PS 48 | C17H15ClO2 | CAS No. 1180676-32-7
Description: PDK1 activator
Chemical Name: (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.

Compound Libraries

PS 48 is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 286.75
Formula C17H15ClO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1180676-32-7
Smiles ClC1=CC=C(CC/C(C2=CC=CC=C2)=C/C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 286.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.44 mL 34.87 mL
5 mM 0.7 mL 3.49 mL 6.97 mL
10 mM 0.35 mL 1.74 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hindie et al (2009) Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat.Chem.Biol. 5 758 PMID: 19718043

Stroba et al (2009) 3,5-diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J.Med.Chem. 52 4683 PMID: 19606904

Williams (2010) Elastic network model of allosteric regulation in protein kinase PDK1. BMC Struct.Biol. 10 11 PMID: 20500829

Zhu et al (2010) Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell. 7 651 PMID: 21112560

View Related Products by Product Action

View all Phosphoinositide-dependent Kinase 1 Activators

Keywords: phosphoinositide-dependent protein kinase 1 pdk1 activators allosteric PS48 Phosphoinositide-dependent Kinase 1

Citations for PS 48

Citations are publications that use Tocris products.

Currently there are no citations for PS 48.

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Reviews

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Literature in this Area

Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for PS 48

Protocols

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