Pricing Availability   Qty
Description: Unnatural amino acid, propargyl lysine derivative
Chemical Name: N6-[(2-Propyn-1-yloxy)carbonyl]-L-lysine hydrochloride
Purity: ≥95%
Literature (1)

Biological Activity for ProK

ProK is a lysine-based unnatural amino acid (UAA) used for genetic code expansion. It enables bioconjugation of fluorescent probes in E. coli or multicellular organisms.

Technical Data for ProK

M. Wt 264.71
Formula C10H16N2O4.HCl
Storage Store at -20°C
Purity ≥95%
CAS Number 1428330-91-9
PubChem ID 118898827
Smiles C(NCCCC[C@@H](C(O)=O)N)(OCC#C)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ProK

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.47 100
water 26.47 100

Preparing Stock Solutions for ProK

The following data is based on the product molecular weight 264.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.78 mL 18.89 mL 37.78 mL
5 mM 0.76 mL 3.78 mL 7.56 mL
10 mM 0.38 mL 1.89 mL 3.78 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for ProK

References are publications that support the biological activity of the product.

Nguyen et al (2009) Genetic encoding and labeling of aliphatic azides and alkynes in recombinant proteins via a pyrrolysyl-tRNA Synthetase/tRNA(CUA) pair and click chemistry. J.Am.Chem.Soc. 131 8720 PMID: 19514718

Neumann et al (2010) Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome. Nature 464 441 PMID: 20154731

Li et al (2014) Palladium-triggered deprotection chemistry for protein activation in living cells. Nat. Chem. 6 352 PMID: 24651204

Greiss et al (2011) Expanding the genetic code of an animal. J.Am.Chem.Soc. 133 14196 PMID: 21819153

Meineke et al (2020) Site-specific incorporation of two ncAAs for two-color bioorthogonal labeling and crosslinking of proteins on live mammalian cells. Cell Rep. 31 107811 PMID: 32579937

If you know of a relevant reference for ProK, please let us know.

View Related Products by Target

Keywords: ProK, ProK supplier, unnatural, amino, acid, protein, non-canonical, tagging, labeling, labelling, UAA, Amino, Acids, Unnatural, 7361, Tocris Bioscience

Citations for ProK

Citations are publications that use Tocris products.

Currently there are no citations for ProK. Do you know of a great paper that uses ProK from Tocris? Please let us know.

Reviews for ProK

There are currently no reviews for this product. Be the first to review ProK and earn rewards!

Have you used ProK?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

  • Fluorescent Dyes, including dyes for flow cytometry
  • Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
  • Tissue Clearing Kits and Reagents
  • Aptamer-based RNA Imaging Reagents
  • Fluorescent Probes for Imaging Bacteria
  • TSA VividTM Fluorophore Kits
  • TSA Reagents for Enhancing IHC, ICC & FISH Signals