Probenecid

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Cat.No. 4107 - Probenecid | C13H19NO4S | CAS No. 57-66-9
Description: MRP and OAT3 inhibitor
Chemical Name: 4-(Dipropylsulfamoyl)benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity for Probenecid

Probenecid is an inhibitor of multidrug resistance-associated proteins (MRP). Also inhibits OAT3 and inhibits organic acid transport in the kidney and other organs. Exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM). Inhibits influenza A virus replication in vitro and in vivo.

Compound Libraries for Probenecid

Probenecid is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Probenecid

M. Wt 285.36
Formula C13H19NO4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 57-66-9
PubChem ID 4911
InChI Key DBABZHXKTCFAPX-UHFFFAOYSA-N
Smiles O=S(C1=CC=C(C(O)=O)C=C1)(N(CCC)CCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Probenecid

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.54 100
ethanol 28.54 100

Preparing Stock Solutions for Probenecid

The following data is based on the product molecular weight 285.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.5 mL 17.52 mL 35.04 mL
5 mM 0.7 mL 3.5 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.5 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for Probenecid

References are publications that support the biological activity of the product.

Cunningham et al (1981) Clinical pharmacokinetics of probe. Clin.Pharmacokinet. 6 135 PMID: 7011657

Hammond et al (2007) Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J.Biol.Chem. 282 14337 PMID: 17374608

Silverman et al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am.J.Physiol.Cell Physiol. 295 C761 PMID: 18596212

Ishikawa et al (2010) Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol.Pharm.Bull. 33 504 PMID: 20190417

Perwitasai et al (2013) Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy. Antimicrob.Agents Chemother. 57 475 PMID: 23129053


If you know of a relevant reference for Probenecid, please let us know.

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Keywords: Probenecid, Probenecid supplier, ATP-binding, cassette, ABC, multidrug, resistance-associated, proteins, MRP, inhibitors, inhibits, Multidrug, Transporters, Influenza, Viruses, 4107, Tocris Bioscience

2 Citations for Probenecid

Citations are publications that use Tocris products. Selected citations for Probenecid include:

Asgari et al (2013) C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. J Biol Chem 122 3473 PMID: 23878142

Ostrovskaya et al (2014) Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci 21 74 PMID: 25096780


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Literature in this Area

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