Probenecid

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: MRP and OAT3 inhibitor
Chemical Name: 4-(Dipropylsulfamoyl)benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (1)

Biological Activity for Probenecid

Probenecid is an inhibitor of multidrug resistance-associated proteins (MRP). Probenicid inhibits OAT3, organic acid transport in the kidney and other organs and exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM). Probenecid potently inhibits SARS-CoV-2 replication in NHBE and Vero E6 cells (IC50 = 1.3 nM and 750 nM, respectively) and reduces lung virus titers in vivo. Probenicid also inhibits influenza A virus replication in vitro and in vivo.

Compound Libraries for Probenecid

Probenecid is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Probenecid

M. Wt 285.36
Formula C13H19NO4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 57-66-9
PubChem ID 4911
InChI Key DBABZHXKTCFAPX-UHFFFAOYSA-N
Smiles O=S(C1=CC=C(C(O)=O)C=C1)(N(CCC)CCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Probenecid

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.54 100
ethanol 28.54 100

Preparing Stock Solutions for Probenecid

The following data is based on the product molecular weight 285.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.5 mL 17.52 mL 35.04 mL
5 mM 0.7 mL 3.5 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.5 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Probenecid

References are publications that support the biological activity of the product.

Cunningham et al (1981) Clinical pharmacokinetics of probe. Clin.Pharmacokinet. 6 135 PMID: 7011657

Hammond et al (2007) Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J.Biol.Chem. 282 14337 PMID: 17374608

Silverman et al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am.J.Physiol.Cell Physiol. 295 C761 PMID: 18596212

Ishikawa et al (2010) Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol.Pharm.Bull. 33 504 PMID: 20190417

Perwitasai et al (2013) Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy. Antimicrob.Agents Chemother. 57 475 PMID: 23129053

Murray et al (2021) Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro. Sci.Rep. 11 PMID: 34508172


If you know of a relevant reference for Probenecid, please let us know.

View Related Products by Product Action

View all Multidrug Transporter Inhibitors

Keywords: Probenecid, Probenecid supplier, ATP-binding, cassette, ABC, multidrug, resistance-associated, proteins, MRP, inhibitors, inhibits, Multidrug, Transporters, Influenza, Viruses, COVID-19, Coronavirus, 4107, Tocris Bioscience

4 Citations for Probenecid

Citations are publications that use Tocris products. Selected citations for Probenecid include:

Juan V et al (2021) Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity? Front Pharmacol 12 613449 PMID: 33867979

Ostrovskaya et al (2014) Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci 21 74 PMID: 25096780

Anna et al (2017) The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. Int J Mol Sci 18 PMID: 28726743

Asgari et al (2013) C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. J Biol Chem 122 3473 PMID: 23878142


Do you know of a great paper that uses Probenecid from Tocris? Please let us know.

Reviews for Probenecid

There are currently no reviews for this product. Be the first to review Probenecid and earn rewards!

Have you used Probenecid?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.