Inhibitor of multidrug resistance-associated proteins (MRP). Inhibits organic acid transport in the kidney and other organs. Also exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 285.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.5 mL||17.52 mL||35.04 mL|
|5 mM||0.7 mL||3.5 mL||7.01 mL|
|10 mM||0.35 mL||1.75 mL||3.5 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Cunningham et al (1981) Clinical pharmacokinetics of probenecid. Clin.Pharmacokinet. 6 135 PMID: 7011657
Hammond et al (2007) Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J.Biol.Chem. 282 14337 PMID: 17374608
Silverman et al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am.J.Physiol.Cell Physiol. 295 C761 PMID: 18596212
Ishikawa et al (2010) Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol.Pharm.Bull. 33 504 PMID: 20190417
If you know of a relevant reference for Probenecid, please let us know.
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Keywords: ATP-binding cassette ABC multidrug resistance-associated proteins MRP inhibitors inhibits Multidrug Transporters
2 Citations for Probenecid
Citations are publications that use Tocris products. Selected citations for Probenecid include:
Ostrovskaya et al (2014) Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci 21 74 PMID: 25096780
Asgari et al (2013) C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. J Biol Chem 122 3473 PMID: 23878142
Do you know of a great paper that uses Probenecid from Tocris? If so please let us know.
Literature in this Area
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