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Submit ReviewPRIMA-1
Description: Restores mutant p53 activity; induces apoptosis
Chemical Name: 2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Purity: ≥99% (HPLC)
Biological Activity for PRIMA-1
PRIMA-1 is a selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.
Technical Data for PRIMA-1
| M. Wt | 185.22 |
| Formula | C9H15NO3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 5608-24-2 |
| PubChem ID | 322968 |
| InChI Key | RFBVBRVVOPAAFS-UHFFFAOYSA-N |
| Smiles | O=C1C(CO)(CO)N2CCC1CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PRIMA-1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 18.52 | 100 |
Preparing Stock Solutions for PRIMA-1
The following data is based on the product molecular weight 185.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.4 mL | 26.99 mL | 53.99 mL |
| 5 mM | 1.08 mL | 5.4 mL | 10.8 mL |
| 10 mM | 0.54 mL | 2.7 mL | 5.4 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.08 mL |
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Product Datasheets for PRIMA-1
References for PRIMA-1
References are publications that support the biological activity of the product.
Bykov et al (2002) Restoration of the tumour suppressor function to mutant p53 by a low-molecular-weight compound. Nat.Med. 8 282 PMID: 11875500
Bykov et al (2002) Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database. Carcinogenesis 23 2011 PMID: 12507923
Wang et al (2007) PRIMA-1 induces apoptosis by inhibiting JNK signalling but promoting the activation of Bax. Biochem.Biophys.Res.Commun. 352 203 PMID: 17113036
If you know of a relevant reference for PRIMA-1, please let us know.
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Keywords: PRIMA-1, PRIMA-1 supplier, Restores, mutant, p53, activity, induces, apoptosis, Transcription, Factors, Bax, PUMA, 1862, Tocris Bioscience
3 Citations for PRIMA-1
Citations are publications that use Tocris products. Selected citations for PRIMA-1 include:
Benakanakere et al (2009) Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: a pilot study. Endocr Relat Cancer 16 85 PMID: 19075036
Cerchietti et al (2008) Sequential transcription factor targeting for diffuse large B-cell lymphomas. Cancer Res 68 3361 PMID: 18451163
Grinter et al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J Neurosci 29 795 PMID: 21315634
Do you know of a great paper that uses PRIMA-1 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Pathways for PRIMA-1
