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Cat.No. 1862 - PRIMA-1 | C9H15NO3 | CAS No. 5608-24-2
Description: Restores mutant p53 activity; induces apoptosis
Chemical Name: 2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity

Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.

Technical Data

M. Wt 185.22
Formula C9H15NO3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 5608-24-2
PubChem ID 322968
Smiles O=C1C(CO)(CO)N2CCC1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 18.52 100
phosphate buffered saline 18.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 185.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.4 mL 26.99 mL 53.99 mL
5 mM 1.08 mL 5.4 mL 10.8 mL
10 mM 0.54 mL 2.7 mL 5.4 mL
50 mM 0.11 mL 0.54 mL 1.08 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Bykov et al (2002) Restoration of the tumour suppressor function to mutant p53 by a low-molecular-weight compound. Nat.Med. 8 282 PMID: 11875500

Bykov et al (2002) Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database. Carcinogenesis 23 2011 PMID: 12507923

Wang et al (2007) PRIMA-1 induces apoptosis by inhibiting JNK signalling but promoting the activation of Bax. Biochem.Biophys.Res.Commun. 352 203 PMID: 17113036

If you know of a relevant reference for PRIMA-1, please let us know.

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Keywords: PRIMA-1, supplier, Restores, mutant, p53, activity, induces, apoptosis, Transcription, Factors, Bax, PUMA, p53, p53, Tocris Bioscience

2 Citations for PRIMA-1

Citations are publications that use Tocris products. Selected citations for PRIMA-1 include:

Grinter et al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J Neurosci 29 795 PMID: 21315634

Benakanakere et al (2009) Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: a pilot study. Endocr Relat Cancer 16 85 PMID: 19075036

Do you know of a great paper that uses PRIMA-1 from Tocris? If so please let us know.

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for PRIMA-1


p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.