pp60 c-src (521-533) (phosphorylated)

Pricing Availability Delivery Time Qty
Cat.No. 1923 - pp60 c-src (521-533) (phosphorylated) | Thr-Ser-Thr-Glu-Pro-Gln-pTyr-Gln-Pro-Gly-Glu-Asn-Leu | CAS No. 149299-77-4
Description: Inhibits tyrosine kinase activity of pp60c-src and pp60v-src
Datasheet
Citations
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Literature

Biological Activity

Peptide corresponding to the pp60c-src carboxy terminal regulatory domain; phosphorylated at Tyr527. Binds to pp60c-src and pp60v-src at the SH2 domain, suppressing their tyrosine kinase activity and transforming potential.

Technical Data

M. Wt 1543.5
Formula C62H95N16O28P
Sequence TSTEPQYQPGENL

(Modifications: Tyr-7 = pTyr)

Storage Store at -20°C
CAS Number 149299-77-4
PubChem ID 16137939
InChI Key QTTDEIYNMOIHBO-VVTMTNTLSA-N
Smiles [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1543.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.65 mL 3.24 mL 6.48 mL
5 mM 0.13 mL 0.65 mL 1.3 mL
10 mM 0.06 mL 0.32 mL 0.65 mL
50 mM 0.01 mL 0.06 mL 0.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Harder et al (1994) Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTP beta) using synthetic phosphopeptides. Biochem.J. 298 395 PMID: 8135747

Roussel et al (1991) Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxy terminus of pp60c-src. Proc.Natl.Acad.Sci.U.S.A. 88 10696 PMID: 1720546


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