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Submit ReviewPoly Vinyl Alcohol
Description: Carrier molecule for stem cell culture; replaces serum albumin for ex vivo stem cell expansion
Biological Activity
Carrier molecule for stem cells. Replaces serum albumin for ex vivo stem cell expansion, circumnavigating the innate immune response invoked by serum albumin.
Average MW 85,000-124,000, 87-89% hydrolyzed
Technical Data
| Storage | Store at RT |
| CAS Number | 9002-89-5 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 40 | INF |
Product Datasheets
References
References are publications that support the biological activity of the product.
Cyranoski et al (2019) Blood stem cells produced in vast quantities in the lab. Nature 570 17 PMID: 31164758
Wilkinson et al (2019) Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. Nature 571 117 PMID: 31142833
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
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Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.