PNU 177864 hydrochloride

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Cat.No. 3355 - PNU 177864 hydrochloride | C18H21F3N2O3S.HCl | CAS No. 1783978-03-9
Description: Highly selective D3 antagonist
Chemical Name: N-[4-[2-(Propylamino)ethyl)phenyl]-4-(trifluoromethoxy)-benzenesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Literature (5)

Biological Activity

Highly selective dopamine D3 receptor antagonist. Induces phospholipidosis and exhibits antischizophrenic activity in vivo.

Technical Data

M. Wt 438.89
Formula C18H21F3N2O3S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1783978-03-9
PubChem ID 56972219
Smiles O=S(C1=CC=C(OC(F)(F)F)C=C1)(NC2=CC=C(CCNCCC)C=C2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 8.78 20
DMSO 43.89 100

Preparing Stock Solutions

The following data is based on the product molecular weight 438.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.39 mL 22.78 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References are publications that support the biological activity of the product.

Vonderfecht et al (2004) Myopathy related to administration of a cationic amphiphilic drug and the use of multidose drug distribution analysis to predict its occurrence. Toxicol.Pathol. 32 318 PMID: 15204973

Rudmann et al (2004) Epididymal and systemic phospholipidosis in rats and dogs treated with DA D3 selective antagonist PNU-177864. Toxicol.Pathol. 32 326 PMID: 15204974

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