PNU 177864 hydrochloride

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Cat.No. 3355 - PNU 177864 hydrochloride | C18H21F3N2O3S.HCl | CAS No. 250266-51-4
Description: Highly selective D3 antagonist
Chemical Name: N-[4-[2-(Propylamino)ethyl)phenyl]-4-(trifluoromethoxy)-benzenesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Highly selective dopamine D3 receptor antagonist. Induces phospholipidosis and exhibits antischizophrenic activity in vivo.

Compound Libraries

PNU 177864 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 438.89
Formula C18H21F3N2O3S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 250266-51-4
PubChem ID 56972219
InChI Key UOMDLHQTLPWCCE-UHFFFAOYSA-N
Smiles O=S(C1=CC=C(OC(F)(F)F)C=C1)(NC2=CC=C(CCNCCC)C=C2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.89 100
water 8.78 20

Preparing Stock Solutions

The following data is based on the product molecular weight 438.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.39 mL 22.78 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Vonderfecht et al (2004) Myopathy related to administration of a cationic amphiphilic drug and the use of multidose drug distribution analysis to predict its occurrence. Toxicol.Pathol. 32 318 PMID: 15204973

Rudmann et al (2004) Epididymal and systemic phospholipidosis in rats and dogs treated with dopamine D3 selective antagonist PNU-177864. Toxicol.Pathol. 32 326 PMID: 15204974


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Citations for PNU 177864 hydrochloride

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Literature in this Area

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Pathways for PNU 177864 hydrochloride

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