PM 102

Pricing Availability   Qty
Cat.No. 4034 - PM 102 | Ac-Ala-Glu-Ala-Arg-Ala-Arg-Arg-Ala-Ala-Ala-Arg-Ala-Ala-Arg-Arg-Ala-Lys-Lys-(ε-Ac-Ala-Glu-Ala-Arg-Ala-Arg-Arg-Ala-Ala-Ala-Arg-Ala-Ala-Arg-Arg-Ala-)-Pro-Dpr-(β-Ac-Ala-Glu-Ala-Arg-Ala-Arg-Arg-Ala-Ala-Ala-Arg-Ala-Ala-Arg-Arg-Ala-)-Glu-NH2 | CAS No. 1234564-95-4
Description: Antagonist of heparin (Cat. No. 2812)
Datasheet
Citations
Reviews
Literature

Biological Activity

Peptide that reverses the anticoagulant effect of heparin (Cat. No. 2812). Potently binds heparin (Kd = 36 nM in vitro).

Licensing Information

Sold under license

Technical Data

M. Wt 5830
Formula C235H425N111O64
Sequence AEARARRAAARAARRAKK(AEARARRAAARAARRA)PX(AEARARRAAARAARRA)EN

(Modifications: Ala-1 = N-terminal Ac, Ala-19 = ε-Ac, X-36 = Dpr, Ala-37 = β-Ac, Glu-53 = C-terminal Amide)

Storage Store at -20°C
CAS Number 1234564-95-4
PubChem ID 16130295
InChI Key ZPNFWUPYTFPOJU-LPYSRVMUSA-N
Smiles C[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)NC(CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 5 mg/ml in water

References

References are publications that support the biological activity of the product.

Cushing et al (2010) Reversal of heparin-induced increases in aPTT in the rat by PM102, a novel he. antagonist. Eur.J.Pharmacol. 635 165 PMID: 20307530

Shenoy et al (1999) Development of he. antagonists with focused biological activity. Curr.Pharmaceut.Des. 5 965

Schick et al (2004) Novel concatameric heparin-binding peptides reverse he. and low-molecular-weight he. anticoagulant activities in patient plasma in vitro and in rats in vivo. Blood 103 4


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Keywords: PM 102, PM 102 supplier, PM102, heparin, antagonists, anticoagulants, HepArrest, Cell, Adhesion, Molecules, 4034, Tocris Bioscience

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