(+)-UH 232 maleate

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Cat.No. 0775 - (+)-UH 232 maleate | C18H29NO.C4H4O4 | CAS No. 1217473-50-1
Description: D2 autoreceptor antagonist. Also D3 partial agonist
Chemical Name: cis-(+)-5-Methoxy-1-methyl-2-(di-N-propylamino)tetralin maleate
Datasheet
Citations
Reviews
Literature

Biological Activity

D2 antagonist (Ki = 72.7 nM in a ligand binding assay; apparent KB = 14.5 nM in a cAMP accumulation assay); displays preferential activity at central dopamine autoreceptors. Stimulates a marked acceleration of dopamine synthesis and turnover. Produces locomotor stimulation. Exhibits little or no activity at central noradrenalin and 5-HT receptors. Also D3 partial agonist.

Technical Data

M. Wt 391.51
Formula C18H29NO.C4H4O4
Storage Store at RT
CAS Number 1217473-50-1
PubChem ID 46830250
InChI Key MEQAJDYHKYAPJE-GUUGRXDUSA-N
Smiles OC(=O)\C=C/C(O)=O.CCCN(CCC)[C@@H]1CCC2=C(C=CC=C2OC)[C@@H]1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 50 mM in water

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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References

References are publications that support the biological activity of the product.

Griffon et al (1995) The preferential DA D3 receptor ligand, (+)-UH 232, is a partial agonist. Eur.J.Pharmacol. 282 R3 PMID: 7498261

Hall and Strange (1997) Evidence that antipsychotic drugs are inverse agonists at D2 DA receptors. Br. J. Pharmacol. 121 731 PMID: 9208141

Johansson et al (1985) Novel DA receptor agonists and antagonists with preferential action on autoreceptors. J.Med.Chem. 28 1049 PMID: 3927002

Svensson et al (1986) (+)-AJ 76 and (+)-UH 232: central stimulants acting as preferential DA autoreceptor antagonists. Naunyn Schmiedebergs Arch.Pharmacol. 334 234 PMID: 2880302


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