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Selective σ1 receptor ligand (KD = 19.1 nM), with little or no activity at σ2 receptors (IC50 > 1000 nM). Inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC50 value is approximately 100 nM). Weak inhibitor of brain 5-HT uptake in vitro. Exhibits neuroprotective and antidepressant effects.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 355.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.62 mL||28.09 mL||56.19 mL|
|2.5 mM||1.12 mL||5.62 mL||11.24 mL|
|5 mM||0.56 mL||2.81 mL||5.62 mL|
|25 mM||0.11 mL||0.56 mL||1.12 mL|
References are publications that support the biological activity of the product.
Akunne et al (2001) Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant. Neuropharmacology 41 138 PMID: 11445194
O'Neill et al (1995) The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia. Eur.J.Pharmacol. 283 217 PMID: 7498313
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