(+)-Igmesine hydrochloride

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Cat.No. 2332 - (+)-Igmesine hydrochloride | C23H29N.HCl | CAS No. 130152-35-1
Description: Selective σ1 ligand; antidepressant
Chemical Name: (R)-(+)-N-Cyclopropylmethyl-α-ethyl-N-methyl-α-[(2E)-3-phenyl-2-propenyl)benzenemethanamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective σ1 receptor ligand (KD = 19.1 nM), with little or no activity at σ2 receptors (IC50 > 1000 nM). Inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC50 value is approximately 100 nM). Weak inhibitor of brain 5-HT uptake in vitro. Exhibits neuroprotective and antidepressant effects.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 355.94
Formula C23H29N.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 130152-35-1
PubChem ID 6438339
InChI Key SCHQQPAJNUHKSV-RSGUCCNWSA-N
Smiles CN(C(CC)(C3=CC=CC=C3)C/C=C/C2=CC=CC=C2)CC1CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.8 50

Preparing Stock Solutions

The following data is based on the product molecular weight 355.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.05 mL 28.09 mL
5 mM 0.56 mL 2.81 mL 5.62 mL
10 mM 0.28 mL 1.4 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Akunne et al (2001) Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant. Neuropharmacology 41 138 PMID: 11445194

O'Neill et al (1995) The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia. Eur.J.Pharmacol. 283 217 PMID: 7498313


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