(+)-Igmesine hydrochloride

Pricing Availability   Qty
Description: Selective σ1 ligand; antidepressant
Chemical Name: (R)-(+)-N-Cyclopropylmethyl-α-ethyl-N-methyl-α-[(2E)-3-phenyl-2-propenyl)benzenemethanamine hydrochloride
Purity: ≥98% (HPLC)

Biological Activity for (+)-Igmesine hydrochloride

(+)-Igmesine hydrochloride is a selective σ1 receptor ligand (KD = 19.1 nM), with little or no activity at σ2 receptors (IC50 > 1000 nM). Inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC50 value is approximately 100 nM). Weak inhibitor of brain 5-HT uptake in vitro. Exhibits neuroprotective and antidepressant effects.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for (+)-Igmesine hydrochloride

(+)-Igmesine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for (+)-Igmesine hydrochloride

M. Wt 355.94
Formula C23H29N.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 130152-35-1
PubChem ID 6438339
Smiles CN(C(CC)(C3=CC=CC=C3)C/C=C/C2=CC=CC=C2)CC1CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (+)-Igmesine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.8 50

Preparing Stock Solutions for (+)-Igmesine hydrochloride

The following data is based on the product molecular weight 355.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.62 mL 28.09 mL 56.19 mL
2.5 mM 1.12 mL 5.62 mL 11.24 mL
5 mM 0.56 mL 2.81 mL 5.62 mL
25 mM 0.11 mL 0.56 mL 1.12 mL

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Product Datasheets for (+)-Igmesine hydrochloride

References for (+)-Igmesine hydrochloride

References are publications that support the biological activity of the product.

Akunne et al (2001) Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant. Neuropharmacology 41 138 PMID: 11445194

O'Neill et al (1995) The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia. Eur.J.Pharmacol. 283 217 PMID: 7498313

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Citations for (+)-Igmesine hydrochloride

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