Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPlumbagin
Description: Induces G2/M cell cycle arrest; anticancer
Chemical Name: 5-Hydroxy-2-methyl-1,4-naphthalenedione
Purity: ≥98% (HPLC)
Biological Activity for Plumbagin
Plumbagin is an anticancer agent. Induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation; inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice. Promotes autophagic cell death in MDA-MB-231 and MCF-7 cells and inhibits Akt/mTOR signaling. Induces intracellular ROS generation in a PI 5-kinase-dependent manner. Also inhibits p300-mediated acetylation of p53.
Technical Data for Plumbagin
| M. Wt | 188.18 |
| Formula | C11H8O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 481-42-5 |
| PubChem ID | 10205 |
| InChI Key | VCMMXZQDRFWYSE-UHFFFAOYSA-N |
| Smiles | CC2=CC(C1=C(C2=O)C=CC=C1O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Plumbagin
References for Plumbagin
References are publications that support the biological activity of the product.
Hsu et al (2006) Plumbagin (5-hydroxy-2-methyl-1,4-napthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase mediated phosphorylation at serine 15 in vitro and in vivo. J.Pharmacol.Exp.Ther. 318 484 PMID: 16632641
Kuo et al (2006) Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells. Mol.Cancer Ther. 5 3209 PMID: 17172425
Lee et al (2012) The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation. PLoS One. 7 e45023 PMID: 23028742
Ravindra et al (2009) Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin. J.Biol.Chem. 284 24453 PMID: 19570987
View Related Products by Target
Keywords: Plumbagin, Plumbagin supplier, anticancer, induces, cell, cycle, arrest, apoptosis, autophagy, death, antiproliferative, p53, phosphorylation, ROS, generation, antitumor, p300, RTK1, Cell, Cycle, Inhibitors, Apoptosis, Inducers, 4761, Tocris Bioscience
Citations for Plumbagin
Citations are publications that use Tocris products.
Currently there are no citations for Plumbagin.
Reviews for Plumbagin
There are currently no reviews for this product. Be the first to review Plumbagin and earn rewards!
Have you used Plumbagin?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.