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Discontinued Product
Plumbagin (Cat. No. 4761) has been withdrawn from sale for commercial reasons.
Description: Induces G2/M cell cycle arrest; anticancer
Chemical Name: 5-Hydroxy-2-methyl-1,4-naphthalenedione
Purity: ≥98% (HPLC)
Biological Activity for Plumbagin
Plumbagin is an anticancer agent. Induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation; inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice. Promotes autophagic cell death in MDA-MB-231 and MCF-7 cells and inhibits Akt/mTOR signaling. Induces intracellular ROS generation in a PI 5-kinase-dependent manner. Also inhibits p300-mediated acetylation of p53.
Technical Data for Plumbagin
| M. Wt | 188.18 |
| Formula | C11H8O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 481-42-5 |
| PubChem ID | 10205 |
| InChI Key | VCMMXZQDRFWYSE-UHFFFAOYSA-N |
| Smiles | CC2=CC(C1=C(C2=O)C=CC=C1O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Plumbagin
References for Plumbagin
References are publications that support the biological activity of the product.
Hsu et al (2006) Plumbagin (5-hydroxy-2-methyl-1,4-napthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase mediated phosphorylation at serine 15 in vitro and in vivo. J.Pharmacol.Exp.Ther. 318 484 PMID: 16632641
Kuo et al (2006) Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells. Mol.Cancer Ther. 5 3209 PMID: 17172425
Lee et al (2012) The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation. PLoS One. 7 e45023 PMID: 23028742
Ravindra et al (2009) Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin. J.Biol.Chem. 284 24453 PMID: 19570987
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Keywords: Plumbagin, Plumbagin supplier, anticancer, induces, cell, cycle, arrest, apoptosis, autophagy, death, antiproliferative, p53, phosphorylation, ROS, generation, antitumor, p300, RTK1, Cell, Cycle, Inhibitors, Apoptosis, Inducers, 4761, Tocris Bioscience
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