Plumbagin

Discontinued Product

Plumbagin (Cat. No. 4761) has been withdrawn from sale for commercial reasons.
Cat.No. 4761 - Plumbagin | C11H8O3 | CAS No. 481-42-5
Description: Induces G2/M cell cycle arrest; anticancer
Chemical Name: 5-Hydroxy-2-methyl-1,4-naphthalenedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for Plumbagin

Plumbagin is an anticancer agent. Induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation; inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice. Promotes autophagic cell death in MDA-MB-231 and MCF-7 cells and inhibits Akt/mTOR signaling. Induces intracellular ROS generation in a PI 5-kinase-dependent manner. Also inhibits p300-mediated acetylation of p53.

Technical Data for Plumbagin

M. Wt 188.18
Formula C11H8O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 481-42-5
PubChem ID 10205
InChI Key VCMMXZQDRFWYSE-UHFFFAOYSA-N
Smiles CC2=CC(C1=C(C2=O)C=CC=C1O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Plumbagin

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.