PKA inhibitor fragment (6-22) amide

Pricing Availability   Qty
Description: Potent protein kinase A inhibitor
Alternative Names: Protein kinase inhibitor-(6-22)-amide, PKI-(6-22)-amide
Purity: ≥95% (HPLC)
Datasheet
Citations (7)
Reviews (1)
Literature (1)

Biological Activity for PKA inhibitor fragment (6-22) amide

PKA inhibitor fragment (6-22) amide is a potent inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM); derived from the active portion of the heat-stable PKA inhibitor protein PKI.

Technical Data for PKA inhibitor fragment (6-22) amide

M. Wt 1868.08
Formula C80H130N28O24
Sequence TYADFIASGRTGRRNAI

(Modifications: Ile-17 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 121932-06-7
PubChem ID 16155227
InChI Key VAKHFAFLRUNHLQ-PEBJKXEYSA-N
Smiles [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PKA inhibitor fragment (6-22) amide

Solubility Soluble to 1 mg/ml in water

Product Datasheets for PKA inhibitor fragment (6-22) amide

Certificate of Analysis / Product Datasheet
Select another batch:

References for PKA inhibitor fragment (6-22) amide

References are publications that support the biological activity of the product.

Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J.Biol.Chem. 264 8802 PMID: 2722799

Glass et al (1989) Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. J.Biol.Chem. 264 14579 PMID: 2760075

Otmakhova et al (2000) Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses. J.Neurosci. 20 4446 PMID: 10844013


If you know of a relevant reference for PKA inhibitor fragment (6-22) amide, please let us know.

View Related Products by Product Action

View all Protein Kinase A Inhibitors

Keywords: PKA Inhibitor Fragment (6-22) amide, PKA Inhibitor Fragment (6-22) amide supplier, Potent, protein, kinases, A, inhibitors, inhibits, PKA, Protein, kinase, inhibitor-(6-22)-amide, PKI-(6-22)-amide, Kinase, 1904, Tocris Bioscience

7 Citations for PKA inhibitor fragment (6-22) amide

Citations are publications that use Tocris products. Selected citations for PKA inhibitor fragment (6-22) amide include:

Cui et al (2016) Endocannabinoid dynamics gate spike-timing dependent depression and potentiation. Elife 5 e13185 PMID: 26920222

O'Neill & Sylantyev (2018) Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C. Exp Biol Med (Maywood) 243 1046 PMID: 30205722

Caiati et al (2013) PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus. J Neurosci 33 2973 PMID: 23407955

Tumati et al (2009) Sustained mor. treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner. J Neurosci 330 810 PMID: 19491327


Do you know of a great paper that uses PKA inhibitor fragment (6-22) amide from Tocris? Please let us know.

Reviews for PKA inhibitor fragment (6-22) amide

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used PKA inhibitor fragment (6-22) amide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


PKI removes PKA control over RMS noise.
By Anonymous on 07/21/2019
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Hippocampus

PKA inhibitor fragment (PKI) was used to compare effects of PKA and G-protein signalling on root mean square noise (RMS) produced by GABA-A receptors in electrophysiological recording. We found that after block of PKA with PKI GABA-A receptor antagonists SR 95531 and Picrotoxin generate stronger impact on RMS noise than after block of G-protein signalling with pertussis toxin.

PMID: 30205722
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis