PKA inhibitor fragment (6-22) amide

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Cat.No. 1904 - PKA Inhibitor Fragment (6-22) amide | Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 | CAS No. 121932-06-7
Description: Potent protein kinase A inhibitor
Alternative Names: Protein kinase inhibitor-(6-22)-amide, PKI-(6-22)-amide
Datasheet
Citations (3)
Literature

Biological Activity

Potent inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM); derived from the active portion of the heat-stable PKA inhibitor protein PKI.

Technical Data

M. Wt 1868.08
Formula C80H130N28O24
Sequence TYADFIASGRTGRRNAI

(Modifications: Ile-17 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 121932-06-7
PubChem ID 16155227
InChI Key VAKHFAFLRUNHLQ-PEBJKXEYSA-N
Smiles [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1868.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.54 mL 2.68 mL 5.35 mL
5 mM 0.11 mL 0.54 mL 1.07 mL
10 mM 0.05 mL 0.27 mL 0.54 mL
50 mM 0.01 mL 0.05 mL 0.11 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J.Biol.Chem. 264 8802 PMID: 2722799

Glass et al (1989) Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. J.Biol.Chem. 264 14579 PMID: 2760075

Otmakhova et al (2000) Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses. J.Neurosci. 20 4446 PMID: 10844013


If you know of a relevant reference for PKA inhibitor fragment (6-22) amide, please let us know.

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Keywords: Potent protein kinases A inhibitors inhibits PKA Protein kinase inhibitor-(6-22)-amide PKI-(6-22)-amide Protein Kinase A

3 Citations for PKA inhibitor fragment (6-22) amide

Citations are publications that use Tocris products. Selected citations for PKA inhibitor fragment (6-22) amide include:

Tumati et al (2009) Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner. J Neurosci 330 810 PMID: 19491327

Hopf et al (2005) Atypical protein kinase C is a novel mediator of dopamine-enhanced firing in nucleus accumbens neurons. FASEB J 25 985 PMID: 15673680

Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545 PMID: 25751534


Do you know of a great paper that uses PKA inhibitor fragment (6-22) amide from Tocris? If so please let us know.

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