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Submit ReviewPIR 3.5
Description: Negative control of IPA 3 (Cat. No. 3622)
Chemical Name: 6,6'-Dithiodi-2-naphthtol
Purity: ≥98% (HPLC)
Biological Activity for PIR 3.5
PIR 3.5 is a negative control of IPA 3, a direct, non-competitive inhibitor of group I p21-activated kinase (Pak1).
Active Analog also available.
Technical Data for PIR 3.5
| M. Wt | 350.45 |
| Formula | C20H14O2S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 6088-51-3 |
| PubChem ID | 22463 |
| InChI Key | AHXGXXJEEHFHDK-UHFFFAOYSA-N |
| Smiles | OC1=CC=C2C(C=CC(SSC3=CC(C=CC(O)=C4)=C4C=C3)=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PIR 3.5
References for PIR 3.5
References are publications that support the biological activity of the product.
Deacon et al (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem.Biol. 15 322 PMID: 18420139
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Keywords: PIR 3.5, PIR 3.5 supplier, PIR, 3.5, PIR3.5, negative, control, IPA-3, inhibits, Pak1, inhibitors, P21-activated, Kinases, 4212, Tocris Bioscience
3 Citations for PIR 3.5
Citations are publications that use Tocris products. Selected citations for PIR 3.5 include:
Imle et al (2015) Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio 6 PMID: 26350970
Molosh et al (2014) Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase. J Biol Chem 17 1583 PMID: 25242307
Das et al (2017) Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala. Sci Rep 7 13930 PMID: 29066727
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