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Negative control of IPA 3, a direct, non-competitive inhibitor of group I p21-activated kinase (Pak1).
Active Analog also available.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 350.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||3.8 mL||19.02 mL||38.05 mL|
|3.75 mM||0.76 mL||3.8 mL||7.61 mL|
|7.5 mM||0.38 mL||1.9 mL||3.8 mL|
|37.5 mM||0.08 mL||0.38 mL||0.76 mL|
References are publications that support the biological activity of the product.
Deacon et al (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem.Biol. 15 322 PMID: 18420139
If you know of a relevant reference for PIR 3.5, please let us know.
Keywords: PIR 3.5, PIR 3.5 supplier, PIR, 3.5, PIR3.5, negative, control, IPA-3, inhibits, Pak1, inhibitors, P21-activated, Kinases, 4212, Tocris Bioscience
3 Citations for PIR 3.5
Citations are publications that use Tocris products. Selected citations for PIR 3.5 include:
Imle et al (2015) Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio 6 PMID: 26350970
Das et al (2017) Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala. Sci Rep 7 13930 PMID: 29066727
Molosh et al (2014) Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase. J Biol Chem 17 1583 PMID: 25242307
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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