Negative control of IPA 3 (Cat. No. 3622) a direct, non-competitive inhibitor of group I p21-activated kinase (Pak1).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 350.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.85 mL||14.27 mL||28.53 mL|
|5 mM||0.57 mL||2.85 mL||5.71 mL|
|10 mM||0.29 mL||1.43 mL||2.85 mL|
|50 mM||0.06 mL||0.29 mL||0.57 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Deacon et al (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem.Biol. 15 322 PMID: 18420139
If you know of a relevant reference for PIR 3.5, please let us know.
Keywords: PIR 3.5 PIR3.5 negative control IPA-3 inhibits Pak1 inhibitors P21-activated Kinases
2 Citations for PIR 3.5
Citations are publications that use Tocris products. Selected citations for PIR 3.5 include:
Imle et al (2015) Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio 6 PMID: 26350970
Molosh et al (2014) Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase. J Biol Chem 17 1583 PMID: 25242307
Do you know of a great paper that uses PIR 3.5 from Tocris? If so please let us know.