PIR 3.5

Pricing Availability Delivery Time Qty
Cat.No. 4212 - PIR 3.5 | C20H14O2S2 | CAS No. 6088-51-3
Description: Negative control of IPA 3 (Cat. No. 3622)
Chemical Name: 6,6'-Dithiodi-2-naphthtol
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Negative control of IPA 3 (Cat. No. 3622) a direct, non-competitive inhibitor of group I p21-activated kinase (Pak1).

Technical Data

M. Wt 350.45
Formula C20H14O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6088-51-3
PubChem ID 22463
InChI Key AHXGXXJEEHFHDK-UHFFFAOYSA-N
Smiles OC1=CC=C2C(C=CC(SSC3=CC(C=CC(O)=C4)=C4C=C3)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.28 75
ethanol 3.5 10

Preparing Stock Solutions

The following data is based on the product molecular weight 350.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.27 mL 28.53 mL
5 mM 0.57 mL 2.85 mL 5.71 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Deacon et al (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem.Biol. 15 322 PMID: 18420139


If you know of a relevant reference for PIR 3.5, please let us know.

View Related Products by Target

Keywords: PIR 3.5 PIR3.5 negative control IPA-3 inhibits Pak1 inhibitors P21-activated Kinases

2 Citations for PIR 3.5

Citations are publications that use Tocris products. Selected citations for PIR 3.5 include:

Imle et al (2015) Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio 6 PMID: 26350970

Molosh et al (2014) Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase. J Biol Chem 17 1583 PMID: 25242307


Do you know of a great paper that uses PIR 3.5 from Tocris? If so please let us know.

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Reviews

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Literature in this Area

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Kinases

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A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Pathways for PIR 3.5

Protocols

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