PIR 3.5

Pricing Availability   Qty
Cat.No. 4212 - PIR 3.5 | C20H14O2S2 | CAS No. 6088-51-3
Description: Negative control of IPA 3 (Cat. No. 3622)
Chemical Name: 6,6'-Dithiodi-2-naphthtol
Purity: ≥98% (HPLC)
Citations (3)
Literature (3)

Biological Activity

Negative control of IPA 3, a direct, non-competitive inhibitor of group I p21-activated kinase (Pak1).

Active Analog also available.

Technical Data

M. Wt 350.45
Formula C20H14O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6088-51-3
PubChem ID 22463
Smiles OC1=CC=C2C(C=CC(SSC3=CC(C=CC(O)=C4)=C4C=C3)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.28 75
ethanol 3.5 10

Preparing Stock Solutions

The following data is based on the product molecular weight 350.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 3.8 mL 19.02 mL 38.05 mL
3.75 mM 0.76 mL 3.8 mL 7.61 mL
7.5 mM 0.38 mL 1.9 mL 3.8 mL
37.5 mM 0.08 mL 0.38 mL 0.76 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References are publications that support the biological activity of the product.

Deacon et al (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem.Biol. 15 322 PMID: 18420139

If you know of a relevant reference for PIR 3.5, please let us know.

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3 Citations for PIR 3.5

Citations are publications that use Tocris products. Selected citations for PIR 3.5 include:

Imle et al (2015) Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio 6 PMID: 26350970

Das et al (2017) Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala. Sci Rep 7 13930 PMID: 29066727

Molosh et al (2014) Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase. J Biol Chem 17 1583 PMID: 25242307

Do you know of a great paper that uses PIR 3.5 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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