PIR 3.5

Discontinued Product

PIR 3.5 (Cat. No. 4212) has been withdrawn from sale for commercial reasons.
Cat.No. 4212 - PIR 3.5 | C20H14O2S2 | CAS No. 6088-51-3
Description: Negative control of IPA 3 (Cat. No. 3622)
Chemical Name: 6,6'-Dithiodi-2-naphthtol
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (3)

Biological Activity for PIR 3.5

PIR 3.5 is a negative control of IPA 3, a direct, non-competitive inhibitor of group I p21-activated kinase (Pak1).

Active Analog also available.

Technical Data for PIR 3.5

M. Wt 350.45
Formula C20H14O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6088-51-3
PubChem ID 22463
InChI Key AHXGXXJEEHFHDK-UHFFFAOYSA-N
Smiles OC1=CC=C2C(C=CC(SSC3=CC(C=CC(O)=C4)=C4C=C3)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PIR 3.5

References are publications that support the biological activity of the product.

Deacon et al (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem.Biol. 15 322 PMID: 18420139

View Related Products by Target

Keywords: PIR 3.5, PIR 3.5 supplier, PIR, 3.5, PIR3.5, negative, control, IPA-3, inhibits, Pak1, inhibitors, P21-activated, Kinases, 4212, Tocris Bioscience

3 Citations for PIR 3.5

Citations are publications that use Tocris products. Selected citations for PIR 3.5 include:

Das et al (2017) Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala. Sci Rep 7 13930 PMID: 29066727

Imle et al (2015) Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio 6 PMID: 26350970

Molosh et al (2014) Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase. J Biol Chem 17 1583 PMID: 25242307


Reviews for PIR 3.5

There are currently no reviews for this product. Be the first to review PIR 3.5 and earn rewards!

Have you used PIR 3.5?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases