PIR 3.5

Discontinued Product

PIR 3.5 (Cat. No. 4212) has been withdrawn from sale for commercial reasons.
Description: Negative control of IPA 3 (Cat. No. 3622)
Chemical Name: 6,6'-Dithiodi-2-naphthtol
Purity: ≥98% (HPLC)
Citations (3)

Biological Activity for PIR 3.5

PIR 3.5 is a negative control of IPA 3, a direct, non-competitive inhibitor of group I p21-activated kinase (Pak1).

Active Analog also available.

Technical Data for PIR 3.5

M. Wt 350.45
Formula C20H14O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6088-51-3
PubChem ID 22463
Smiles OC1=CC=C2C(C=CC(SSC3=CC(C=CC(O)=C4)=C4C=C3)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PIR 3.5

References are publications that support the biological activity of the product.

Deacon et al (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem.Biol. 15 322 PMID: 18420139

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3 Citations for PIR 3.5

Citations are publications that use Tocris products. Selected citations for PIR 3.5 include:

Molosh et al (2014) Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase. J Biol Chem 17 1583 PMID: 25242307

Das et al (2017) Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala. Sci Rep 7 13930 PMID: 29066727

Imle et al (2015) Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio 6 PMID: 26350970

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