Pimozide

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Cat.No. 0937 - Pimozide | C28H29F2N3O | CAS No. 2062-78-4
Description: D2-like antagonist
Chemical Name: 1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Dopamine D2-receptor antagonist and antipsychotic which binds with very high affinity to the cloned rat 5-HT7 receptor (Ki = 0.5 nM).

Compound Libraries

Pimozide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 461.55
Formula C28H29F2N3O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2062-78-4
PubChem ID 16362
InChI Key YVUQSNJEYSNKRX-UHFFFAOYSA-N
Smiles FC1=CC=C(C=C1)C(CCCN1CCC(CC1)N1C(=O)NC2=CC=CC=C12)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.23 20

Preparing Stock Solutions

The following data is based on the product molecular weight 461.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Roth et al (1994) Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J.Pharmacol.Exp.Ther. 268 1403 PMID: 7908055

Merck Index 12 7589 PMID:


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Keywords: Pimozide, supplier, D2-like, antagonists, High, affinity, 5-HT7, D2, Dopamine, Non-Selective, Receptors, Serotonin, 5-Hydroxytryptamine, dopaminergic, Non-selective, Dopamine, Tocris Bioscience

Citations for Pimozide

Citations are publications that use Tocris products.

Currently there are no citations for Pimozide. Do you know of a great paper that uses Pimozide from Tocris? If so please let us know.

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Pathways for Pimozide

Protocols

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