PIK 93

Discontinued Product

PIK 93 (Cat. No. 6440) has been withdrawn from sale for commercial reasons.
Description: Potent PI 3-Kγ, PI 3-Kα and PI 4-KIIIβ inhibitor
Chemical Name: N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazoly]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for PIK 93

PIK 93 is a potent PI 3-Kγ, PI 3-Kα and PI 4-KIIIβ inhibitor (IC50 values are 16, 39 and 19 nM, respectively). Rescues PI 3K inhibition of growth of S. cerevisiae in a reverse halo assay.

Technical Data for PIK 93

M. Wt 389.88
Formula C14H16CIN3O4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 593960-11-3
PubChem ID 6852167
InChI Key JFVNFXCESCXMBC-UHFFFAOYSA-N
Smiles CC(NC1=NC(C)=C(C2=CC(S(=O)(NCCO)=O)=C(C=C2)Cl)S1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PIK 93

References are publications that support the biological activity of the product.

Burke et al (2014) Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab1 1 and its effectors. Science 344 1035 PMID: 24876499

Zunder et al (2008) Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 α. Cancer Cell 14 180 PMID: 18691552

Knight et al (2006) A pharmacological map of the PI3-K family defines a role for p110α in Ins signaling. Cell 125 733 PMID: 16647110

View Related Products by Product Action

View all PI 3-kinase Inhibitors

Keywords: PIK 93, PIK 93 supplier, PIK93, Potent, PI, 3-Kgamma, 3-Kalpha, 4-KIIIbeta, inhibitors, inhibits, phosphoinositide, 3-kinase, 4-kinase, γ, β, α, 3-Kinase, Other, Kinases, 6440, Tocris Bioscience

Citations for PIK 93

Citations are publications that use Tocris products.

Currently there are no citations for PIK 93.

Reviews for PIK 93

There are currently no reviews for this product. Be the first to review PIK 93 and earn rewards!

Have you used PIK 93?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review