PIK 93

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Cat.No. 6440 - PIK 93 | C14H16ClN3O4S2 | CAS No. 593960-11-3
Description: Potent PI 3-Kγ, PI 3-Kα and PI 4-KIIIβ inhibitor
Chemical Name: N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazoly]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent PI 3-Kγ, PI 3-Kα and PI 4-KIIIβ inhibitor (IC50 values are 16, 39 and 19 nM, respectively). Rescues PI 3K inhibition of growth of S. cerevisiae in a reverse halo assay.

Technical Data

M. Wt 389.88
Formula C14H16CIN3O4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 593960-11-3
PubChem ID 6852167
InChI Key JFVNFXCESCXMBC-UHFFFAOYSA-N
Smiles CC(NC1=NC(C)=C(C2=CC(S(=O)(NCCO)=O)=C(C=C2)Cl)S1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.99 100

Preparing Stock Solutions

The following data is based on the product molecular weight 389.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.82 mL 25.65 mL
5 mM 0.51 mL 2.56 mL 5.13 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Burke et al (2014) Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab1 1 and its effectors. Science 344 1035 PMID: 24876499

Zunder et al (2008) Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 α. Cancer Cell 14 180 PMID: 18691552

Knight et al (2006) A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling. Cell 125 733 PMID: 16647110


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Keywords: PIK 93, PIK 93 supplier, PIK93, Potent, PI, 3-Kgamma, 3-Kalpha, 4-KIIIbeta, inhibitors, inhibits, phosphoinositide, 3-kinase, 4-kinase, γ, β, α, 3-Kinase, Other, Kinases, 6440, Tocris Bioscience

Citations for PIK 93

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