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Biological Activity for PIK 93
PIK 93 is a potent PI 3-Kγ, PI 3-Kα and PI 4-KIIIβ inhibitor (IC50 values are 16, 39 and 19 nM, respectively). Rescues PI 3K inhibition of growth of S. cerevisiae in a reverse halo assay.
Technical Data for PIK 93
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PIK 93
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PIK 93
The following data is based on the product molecular weight 389.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.56 mL||12.82 mL||25.65 mL|
|5 mM||0.51 mL||2.56 mL||5.13 mL|
|10 mM||0.26 mL||1.28 mL||2.56 mL|
|50 mM||0.05 mL||0.26 mL||0.51 mL|
References for PIK 93
References are publications that support the biological activity of the product.
Burke et al (2014) Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab1 1 and its effectors. Science 344 1035 PMID: 24876499
Zunder et al (2008) Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 α. Cancer Cell 14 180 PMID: 18691552
Knight et al (2006) A pharmacological map of the PI3-K family defines a role for p110α in Ins signaling. Cell 125 733 PMID: 16647110
If you know of a relevant reference for PIK 93, please let us know.
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Keywords: PIK 93, PIK 93 supplier, PIK93, Potent, PI, 3-Kgamma, 3-Kalpha, 4-KIIIbeta, inhibitors, inhibits, phosphoinositide, 3-kinase, 4-kinase, γ, β, α, 3-Kinase, Other, Kinases, 6440, Tocris Bioscience
Citations for PIK 93
Citations are publications that use Tocris products.
Currently there are no citations for PIK 93. Do you know of a great paper that uses PIK 93 from Tocris? Please let us know.
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Literature in this Area
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