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PI 3065

Cat. No. 5919 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective PI 3-kinase p110δ inhibitor
Chemical Name: 6-[[4-(Cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PI 3065

PI 3065 is a potent and selective PI 3-kinase p110δ inhibitor (IC50 = 5 nM; Ki = 1.5 nM). Exhibits >100-fold selectivity over p100α, p100γ and p100β isoforms (IC50 values are 600, 910, >10,000 nM, respectively). Attenuates 4TI tumor growth and metastasis in vivo.

Technical Data for PI 3065

M. Wt 506.64
Formula C27H31FN6OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 955977-50-1
PubChem ID 24937012
InChI Key YDNOHCOYQVZOMC-UHFFFAOYSA-N
Smiles FC1=CC=C2NC=CC2=C1C3=NC(N4CCOCC4)=C5SC(CN6CCN(CC6)CC7CC7)=CC5=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PI 3065

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.13 20

Preparing Stock Solutions for PI 3065

The following data is based on the product molecular weight 506.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.87 mL 49.34 mL 98.69 mL
1 mM 1.97 mL 9.87 mL 19.74 mL
2 mM 0.99 mL 4.93 mL 9.87 mL
10 mM 0.2 mL 0.99 mL 1.97 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets for PI 3065

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for PI 3065

References are publications that support the biological activity of the product.

Ali et al (2014) Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature 510 407 PMID: 24919154

Porta et al (2014) Targeting PI3K/Akt/mTOR signaling in cancer. Front.Oncol. 4 64 PMID: 24782981

If you know of a relevant reference for PI 3065, please let us know.

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Keywords: PI 3065, PI 3065 supplier, PI, 3-kinase, PI3K, phosphoinositide, 3-kinases, inhibitors, inhibits, potent, selective, p110d, delta, δ, 3-Kinase, 5919, Tocris Bioscience

1 Citation for PI 3065

Citations are publications that use Tocris products. Selected citations for PI 3065 include:

Cornelis F et al (2017) Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells. Immunity 47 1067-1082.e12 PMID: 29246441

Do you know of a great paper that uses PI 3065 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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