PI 3065

Discontinued Product

PI 3065 (Cat. No. 5919) has been withdrawn from sale for commercial reasons.
Description: Potent and selective PI 3-kinase p110δ inhibitor
Chemical Name: 6-[[4-(Cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for PI 3065

PI 3065 is a potent and selective PI 3-kinase p110δ inhibitor (IC50 = 5 nM; Ki = 1.5 nM). Exhibits >100-fold selectivity over p100α, p100γ and p100β isoforms (IC50 values are 600, 910, >10,000 nM, respectively). Attenuates 4TI tumor growth and metastasis in vivo.

Technical Data for PI 3065

M. Wt 506.64
Formula C27H31FN6OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 955977-50-1
PubChem ID 24937012
InChI Key YDNOHCOYQVZOMC-UHFFFAOYSA-N
Smiles FC1=CC=C2NC=CC2=C1C3=NC(N4CCOCC4)=C5SC(CN6CCN(CC6)CC7CC7)=CC5=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for PI 3065

Certificate of Analysis / Product Datasheet
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References for PI 3065

References are publications that support the biological activity of the product.

Ali et al (2014) Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature 510 407 PMID: 24919154

Porta et al (2014) Targeting PI3K/Akt/mTOR signaling in cancer. Front.Oncol. 4 64 PMID: 24782981

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Keywords: PI 3065, PI 3065 supplier, PI, 3-kinase, PI3K, phosphoinositide, 3-kinases, inhibitors, inhibits, potent, selective, p110d, delta, δ, 3-Kinase, 5919, Tocris Bioscience

1 Citation for PI 3065

Citations are publications that use Tocris products. Selected citations for PI 3065 include:

Cornelis F et al (2017) Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells. Immunity 47 1067-1082.e12 PMID: 29246441


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