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PI 3065

Cat. No. 5919 Submit a Review Datasheet / COA / SDS
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Description: Potent and selective PI 3-kinase p110δ inhibitor
Chemical Name: 6-[[4-(Cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PI 3065

PI 3065 is a potent and selective PI 3-kinase p110δ inhibitor (IC50 = 5 nM; Ki = 1.5 nM). Exhibits >100-fold selectivity over p100α, p100γ and p100β isoforms (IC50 values are 600, 910, >10,000 nM, respectively). Attenuates 4TI tumor growth and metastasis in vivo.

Technical Data for PI 3065

M. Wt 506.64
Formula C27H31FN6OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 955977-50-1
PubChem ID 24937012
InChI Key YDNOHCOYQVZOMC-UHFFFAOYSA-N
Smiles FC1=CC=C2NC=CC2=C1C3=NC(N4CCOCC4)=C5SC(CN6CCN(CC6)CC7CC7)=CC5=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PI 3065

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.13 20

Preparing Stock Solutions for PI 3065

The following data is based on the product molecular weight 506.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.87 mL 49.34 mL 98.69 mL
1 mM 1.97 mL 9.87 mL 19.74 mL
2 mM 0.99 mL 4.93 mL 9.87 mL
10 mM 0.2 mL 0.99 mL 1.97 mL

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Product Datasheets for PI 3065

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for PI 3065

References are publications that support the biological activity of the product.

Ali et al (2014) Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature 510 407 PMID: 24919154

Porta et al (2014) Targeting PI3K/Akt/mTOR signaling in cancer. Front.Oncol. 4 64 PMID: 24782981

If you know of a relevant reference for PI 3065, please let us know.

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Keywords: PI 3065, PI 3065 supplier, PI, 3-kinase, PI3K, phosphoinositide, 3-kinases, inhibitors, inhibits, potent, selective, p110d, delta, δ, 3-Kinase, 5919, Tocris Bioscience

Citations for PI 3065

Citations are publications that use Tocris products.

Currently there are no citations for PI 3065. Do you know of a great paper that uses PI 3065 from Tocris? Please let us know.

Reviews for PI 3065

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Literature in this Area

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