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PHPS1 sodium salt
Shp2 (PTPN11) inhibitor (IC50 = 2.1 μM). Inhibits hepatocyte growth factor-stimulated epithelial cell scattering and branching morphogenesis in vitro. Increases myelin basic protein (MBP) levels in zebrafish embryo spinal cord. Also ameliorates bleomycin-induced pulmonary and dermal fibrosis in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 487.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.26 mL||51.29 mL||102.58 mL|
|1 mM||2.05 mL||10.26 mL||20.52 mL|
|2 mM||1.03 mL||5.13 mL||10.26 mL|
|10 mM||0.21 mL||1.03 mL||2.05 mL|
References are publications that support the biological activity of the product.
Hellmuth et al (2008) Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proc.Natl.Acad.Sci.U.S.A 105 7275 PMID: 18480264
Ahrendsen et al (2018) The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination. J.Neurosci. 38 787 PMID: 29217681
Zehender et al (2018) The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nat.Commun. 9 3259 PMID: 30108215
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Keywords: PHPS1 sodium salt, PHPS1 sodium salt supplier, shp2, ptpn11, inhibitors, inhibits, myelination, fibrosis, Protein, Tyrosine, Phosphatases, 6771, Tocris Bioscience
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