PHP 501 trifluoroacetate

Pricing Availability Delivery Time Qty
Cat.No. 4466 - PHP 501 trifluoroacetate | C20H21N3O.CF3CO2H | CAS No. 1236105-75-1
Description: Potent GABAA antagonist
Chemical Name: 4-(5-[1,1'-Biphenyl]-3-yl-1-hydroxy-1H-pyrazol-4-yl)piperidine trifluoroacetate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters.

Compound Libraries

PHP 501 trifluoroacetate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 433.42
Formula C20H21N3O.CF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1236105-75-1
PubChem ID 90488945
InChI Key SULXXKLCQRXMHP-UHFFFAOYSA-N
Smiles ON1N=CC(C3CCNCC3)=C1C2=CC=CC(C4=CC=CC=C4)=C2.FC(F)(C(O)=O)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.34 100
ethanol 4.33 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 433.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.54 mL 23.07 mL
5 mM 0.46 mL 2.31 mL 4.61 mL
10 mM 0.23 mL 1.15 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Møller et al (2010) Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. J.Med.Chem. 53 3417 PMID: 20355712


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1 Citation for PHP 501 trifluoroacetate

Citations are publications that use Tocris products. Selected citations for PHP 501 trifluoroacetate include:

León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206 PMID: 26755241


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Pathways for PHP 501 trifluoroacetate

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