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Submit ReviewPHP 501 trifluoroacetate is a potent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters.
M. Wt | 433.42 |
Formula | C20H21N3O.CF3CO2H |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 1781880-44-1 |
PubChem ID | 90488945 |
InChI Key | SULXXKLCQRXMHP-UHFFFAOYSA-N |
Smiles | ON1N=CC(C3CCNCC3)=C1C2=CC=CC(C4=CC=CC=C4)=C2.FC(F)(C(O)=O)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 43.34 | 100 |
The following data is based on the product molecular weight 433.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.31 mL | 11.54 mL | 23.07 mL |
5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
10 mM | 0.23 mL | 1.15 mL | 2.31 mL |
50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
References are publications that support the biological activity of the product.
Møller et al (2010) Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. J.Med.Chem. 53 3417 PMID: 20355712
If you know of a relevant reference for PHP 501 trifluoroacetate, please let us know.
Keywords: PHP 501 trifluoroacetate, PHP 501 trifluoroacetate supplier, GABAA, receptors, antagonists, potent, PHP501, Receptors, 4466, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for PHP 501 trifluoroacetate include:
León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206 PMID: 26755241
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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