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Phosphoramidon disodium salt is a neutral endopeptidase (neprilysin) inhibitor. Blocks degradation of amyloid β peptides and increases Aβ levels in rodents. Also blocks endothelin converting enzyme (ECE).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 587.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.7 mL||8.51 mL||17.02 mL|
|5 mM||0.34 mL||1.7 mL||3.4 mL|
|10 mM||0.17 mL||0.85 mL||1.7 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
References are publications that support the biological activity of the product.
Marr and Hafez (2014) Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance. Front.Aging Neurosci. 6 187 PMID: 25165447
Shirotani et al (2001) Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J.Biol.Chem. 276 21895 PMID: 11278416
Warner et al (1992) Regional differences in endothelin converting enzyme activity in rat brain: inhibition by phosphoramidon and EDTA. Br.J.Pharmacol. 106 948 PMID: 1393292
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Keywords: Phosphoramidon disodium salt, Phosphoramidon disodium salt supplier, neprilysin, neutral, metallo, endopeptidase, endothelin, converting, enzyme, ECE, inhibitors, inhibits, 119942-99-3, NEP, CD10, MME, Other, Proteases, 6333, Tocris Bioscience
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