Phosphoramidon disodium salt

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Cat.No. 6333 - Phosphoramidon disodium salt | C23H32N3Na2O10P | CAS No. 164204-38-0
Description: Neutral endopeptidase and endothelin converting enzyme inhibitor
Chemical Name: N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Neutral endopeptidase (neprilysin) inhibitor. Blocks degradation of amyloid β peptides and increases Aβ levels in rodents. Also blocks endothelin converting enzyme (ECE).

Technical Data

M. Wt 587.47
Formula C23H32N3Na2O10P
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 164204-38-0
PubChem ID 16219931
InChI Key OQKHVXFOYFBMDJ-ODIUWQMJSA-L
Smiles CC(C[C@@H](C(N[C@H](C(O[Na])=O)CC1=CNC2=CC=CC=C12)=O)NP(O[C@@H]3O[C@H]([C@@H]([C@H]([C@H]3O)O)O)C)(O[Na])=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 58.75 100

Preparing Stock Solutions

The following data is based on the product molecular weight 587.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.7 mL 8.51 mL 17.02 mL
5 mM 0.34 mL 1.7 mL 3.4 mL
10 mM 0.17 mL 0.85 mL 1.7 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Marr and Hafez (2014) Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance. Front.Aging Neurosci. 6 187 PMID: 25165447

Shirotani et al (2001) Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J.Biol.Chem. 276 21895 PMID: 11278416

Warner et al (1992) Regional differences in endothelin converting enzyme activity in rat brain: inhibition by phosphoramidon and EDTA. Br.J.Pharmacol. 106 948 PMID: 1393292


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Keywords: Phosphoramidon disodium salt, supplier, neprilysin, neutral, endopeptidase, endothelin, converting, enzyme, ECE, inhibitors, inhibits, Other, Proteases, Other, Proteases, Tocris Bioscience

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