Phenobarbital sodium salt

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Cat.No. 4578 - Phenobarbital sodium salt | C12H11N2NaO3 | CAS No. 57-30-7
Description: Enhances GABAergic activity
Chemical Name: 5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione sodium salt

Biological Activity

Enhances GABAergic activity. Long-acting barbiturate; slow-acting barbiturate (Cat. No. 4579) also available.

Technical Data

M. Wt 254.22
Formula C12H11N2NaO3
Storage Store at RT
CAS Number 57-30-7
PubChem ID 12598276
Smiles [Na+].CCC1(C(=O)NC([O-])=NC1=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 25.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 254.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.67 mL 39.34 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet


References are publications that support the products' biological activity.

Nardou et al (2011) Phenobarbital but not diazepam reduces AMPA/kainate receptor mediated currents and exerts opposite actions on initial seizures in the neonatal rat hippocampus. Front.Cell.Neurosci. 5 Epub PMID: 21847371

ffrench-Mullen et al (1993) Calcium current block by (-)-pentobarbital, phenobarbital, and CHEB but not (+)-pentobarbital in acutely isolated hippocampal CA1 neurons: comparison with effects on GABA-activated Cl- current. J.Neurosci. 13 3211 PMID: 8101867

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Keywords: Phenobarbital barbiturates anticonvulsants GABAergic GABA Miscellaneous GABA

Citations for Phenobarbital sodium salt

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Literature in this Area

GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Pathways for Phenobarbital sodium salt


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