Phenobarbital sodium salt

Pricing Availability Delivery Time Qty
Cat.No. 4578 - Phenobarbital sodium salt | C12H11N2NaO3 | CAS No. 57-30-7
Description: Enhances GABAergic activity
Chemical Name: 5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione sodium salt
Datasheet
Citations
Literature

Biological Activity

Enhances GABAergic activity. Long-acting barbiturate; slow-acting barbiturate (Cat. No. 4579) also available.

Technical Data

M. Wt 254.22
Formula C12H11N2NaO3
Storage Store at RT
CAS Number 57-30-7
PubChem ID 12598276
InChI Key WRLGYAWRGXKSKG-UHFFFAOYSA-M
Smiles [Na+].CCC1(C(=O)NC([O-])=NC1=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 254.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.67 mL 39.34 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Nardou et al (2011) Phenobarbital but not diazepam reduces AMPA/kainate receptor mediated currents and exerts opposite actions on initial seizures in the neonatal rat hippocampus. Front.Cell.Neurosci. 5 Epub PMID: 21847371

ffrench-Mullen et al (1993) Calcium current block by (-)-pentobarbital, phenobarbital, and CHEB but not (+)-pentobarbital in acutely isolated hippocampal CA1 neurons: comparison with effects on GABA-activated Cl- current. J.Neurosci. 13 3211 PMID: 8101867


If you know of a relevant reference for Phenobarbital sodium salt, please let us know.

Keywords: Phenobarbital barbiturates anticonvulsants GABAergic GABA Miscellaneous GABA

Citations for Phenobarbital sodium salt

Citations are publications that use Tocris products.

Currently there are no citations for Phenobarbital sodium salt. Do you know of a great paper that uses Phenobarbital sodium salt from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Pathways for Phenobarbital sodium salt

Protocols

TODO: Add Protocols