Phaclofen

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Cat.No. 0178 - Phaclofen | C9H13ClNO3P | CAS No. 114012-12-3
Description: Selective GABAB antagonist
Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylphosphonic acid
Purity: ≥97% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Selective GABAB antagonist. Phosphono analog of GABAB agonist baclofen (Cat. No. 0417).

Technical Data

M. Wt 249.63
Formula C9H13ClNO3P
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 114012-12-3
PubChem ID 1641
InChI Key VSGNGLJPOGUDON-UHFFFAOYSA-N
Smiles ClC1=CC=C(C(CN)CP(O)(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 6.24 25

Preparing Stock Solutions

The following data is based on the product molecular weight 249.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 16.02 mL 80.12 mL 160.24 mL
1.25 mM 3.2 mL 16.02 mL 32.05 mL
2.5 mM 1.6 mL 8.01 mL 16.02 mL
12.5 mM 0.32 mL 1.6 mL 3.2 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hasuo and Gallagher (1988) Comparison of antagonism by phaclofen of bac. induced hyperpolarization and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons. Neurosci.Lett. 86 77 PMID: 3362432

Karlsson et al (1988) Phaclofen: a GABAB blocker reduced long-duration inhibition in the neocortex. Eur.J.Pharmacol. 148 485 PMID: 2838310

Kerr et al (1987) Phaclofen: a peripheral and central bac. antagonist. Brain Res. 405 150 PMID: 3032346


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Keywords: Phaclofen, Phaclofen supplier, selective, GABAB, antagonists, Receptors, 0178, Tocris Bioscience

3 Citations for Phaclofen

Citations are publications that use Tocris products. Selected citations for Phaclofen include:

Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol 131 1050 PMID: 11082110

Ibbotson et al (1997) Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurones in vitro. Br J Pharmacol 122 956 PMID: 9384515

Dulcis et al (2017) Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference. Neuron 95 1319 PMID: 28867550


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