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Selective GABAB antagonist. Phosphono analog of GABAB agonist baclofen (Cat. No. 0417).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 249.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||16.02 mL||80.12 mL||160.24 mL|
|1.25 mM||3.2 mL||16.02 mL||32.05 mL|
|2.5 mM||1.6 mL||8.01 mL||16.02 mL|
|12.5 mM||0.32 mL||1.6 mL||3.2 mL|
References are publications that support the biological activity of the product.
Hasuo and Gallagher (1988) Comparison of antagonism by phaclofen of bac. induced hyperpolarization and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons. Neurosci.Lett. 86 77 PMID: 3362432
Karlsson et al (1988) Phaclofen: a GABAB blocker reduced long-duration inhibition in the neocortex. Eur.J.Pharmacol. 148 485 PMID: 2838310
Kerr et al (1987) Phaclofen: a peripheral and central bac. antagonist. Brain Res. 405 150 PMID: 3032346
If you know of a relevant reference for Phaclofen, please let us know.
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Keywords: Phaclofen, Phaclofen supplier, selective, GABAB, antagonists, Receptors, 0178, Tocris Bioscience
3 Citations for Phaclofen
Citations are publications that use Tocris products. Selected citations for Phaclofen include:
Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol 131 1050 PMID: 11082110
Ibbotson et al (1997) Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurones in vitro. Br J Pharmacol 122 956 PMID: 9384515
Dulcis et al (2017) Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference. Neuron 95 1319 PMID: 28867550
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.