Selective GABAB antagonist. Phosphono analog of GABAB agonist baclofen (Cat. No. 0417).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 249.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.01 mL||20.03 mL||40.06 mL|
|5 mM||0.8 mL||4.01 mL||8.01 mL|
|10 mM||0.4 mL||2 mL||4.01 mL|
|50 mM||0.08 mL||0.4 mL||0.8 mL|
References are publications that support the products' biological activity.
Hasuo and Gallagher (1988) Comparison of antagonism by phaclofen of baclofen induced hyperpolarization and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons. Neurosci.Lett. 86 77 PMID: 3362432
Karlsson et al (1988) Phaclofen: a GABAB blocker reduced long-duration inhibition in the neocortex. Eur.J.Pharmacol. 148 485 PMID: 2838310
Kerr et al (1987) Phaclofen: a peripheral and central baclofen antagonist. Brain Res. 405 150 PMID: 3032346
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Keywords: Phaclofen, supplier, selective, GABAB, antagonists, Receptors, GABAB, Receptors, GABAB, Receptors, Tocris Bioscience
1 Citation for Phaclofen
Citations are publications that use Tocris products. Selected citations for Phaclofen include:
Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol 131 1050 PMID: 11082110
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