A potent analgesic and nootropic agent. Increases release of acetylcholine.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 468.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.14 mL||10.68 mL||21.35 mL|
|5 mM||0.43 mL||2.14 mL||4.27 mL|
|10 mM||0.21 mL||1.07 mL||2.14 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References are publications that support the products' biological activity.
Ghelardini et al (1998) Antinociceptive and antiamnesic properties of the presynaptic cholinergic amplifier PG-9. J.Pharmacol.Exp.Ther. 284 806 PMID: 9495837
Gualtieri et al (1994) Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters. J.Med.Chem. 37 1704 PMID: 8201605
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Keywords: PG-9 maleate, supplier, Presynaptic, cholinergic, modulators, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, release, Other, Acetylcholine, Non-selective, Muscarinics, Other, Acetylcholine, Tocris Bioscience
Citations for PG-9 maleate
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.