PG-9 maleate

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Cat.No. 0750 - PG-9 maleate | C17H22BrNO2.C4H4O4 | CAS No. 155649-00-6
Description: Presynaptic cholinergic modulator
Chemical Name: Tropanyl 2-(4-bromophenyl)propionate maleate
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Citations
Reviews
Literature

Biological Activity

A potent analgesic and nootropic agent. Increases release of acetylcholine.

Technical Data

M. Wt 468.34
Formula C17H22BrNO2.C4H4O4
Storage Store at RT
CAS Number 155649-00-6
PubChem ID 46905315
InChI Key VBUSCULTLLOSLM-BTJKTKAUSA-N
Smiles OC(=O)\C=C/C(O)=O.CC(C(=O)OC1CC2CCC(C1)N2C)C1=CC=C(Br)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 468.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.14 mL 10.68 mL 21.35 mL
5 mM 0.43 mL 2.14 mL 4.27 mL
10 mM 0.21 mL 1.07 mL 2.14 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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References

References are publications that support the biological activity of the product.

Ghelardini et al (1998) Antinociceptive and antiamnesic properties of the presynaptic cholinergic amplifier PG-9. J.Pharmacol.Exp.Ther. 284 806 PMID: 9495837

Gualtieri et al (1994) Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters. J.Med.Chem. 37 1704 PMID: 8201605


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Keywords: PG-9 maleate, PG-9 maleate supplier, Presynaptic, cholinergic, modulators, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, release, Other, Non-selective, Muscarinics, 0750, Tocris Bioscience

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