PF 06650833

Pricing Availability   Qty
Description: Potent and selective IRAK4 inhibitor
Chemical Name: 1-[[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews (1)

Biological Activity for PF 06650833

PF 06650833 is a potent and selective IRAK4 inhibitor (IC50 = 2 nM). Inhibits LPS-induced TNF-α secretion in vivo. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 06650833

M. Wt 361.37
Formula C18H20FN3O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1817626-54-2
PubChem ID 118414016
InChI Key JKDGKIBAOAFRPJ-ZBINZKHDSA-N
Smiles CC[C@H]1[C@H](NC([C@H]1F)=O)COC2=NC=CC3=C2C=C(C(C(N)=O)=C3)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PF 06650833

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.14 100

Preparing Stock Solutions for PF 06650833

The following data is based on the product molecular weight 361.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.84 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets for PF 06650833

Certificate of Analysis / Product Datasheet
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References for PF 06650833

References are publications that support the biological activity of the product.

Lee et al (2017) Discovery of clinical candidate 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a potent, selective inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) J.Med.Chem. 60 6621 PMID: 28498658


If you know of a relevant reference for PF 06650833, please let us know.

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Keywords: PF 06650833, PF 06650833 supplier, PF06650833, IRAK4, Interleukin-1, receptor-associated, kinases, potent, selective, orally, bioavailable, IRAK, Cytokines, 6373, Tocris Bioscience

2 Citations for PF 06650833

Citations are publications that use Tocris products. Selected citations for PF 06650833 include:

Clare E et al (2022) The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep 40 111225 PMID: 35977521

Jianfeng et al (2022) Interleukin-1 receptor-associated kinase 4 (IRAK4) in the nucleus accumbens regulates opioid-seeking behavior in male rats. Brain Behav Immun 101 37-48 PMID: 34958862


Do you know of a great paper that uses PF 06650833 from Tocris? Please let us know.

Reviews for PF 06650833

Average Rating: 5 (Based on 1 Review.)

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Works well for kinase assay.
By Scott Scarneo on 02/06/2019
Assay Type: In Vitro
Species: Human

Easy to use and store. I used this assay for a kinase assay against TAK1 in vitro of purified TAK-TAB1.

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