PF 04479745

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Cat.No. 5755 - PF 04479745 | C17H22N4 | CAS No. 1065110-43-1
Description: Potent and selective 5-HT2C agonist
Chemical Name: (9S)-6,7,8,9-Tetrahydro-N,9-dimethyl-2-(phenylmethyl)-5H-pyrimido[4,5-d]azepin-4-amine
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity

Potent and selective 5-HT2C agonist (EC50 = 10 nM). Exhibits > 100-fold selectivity over a panel of 90 receptors, enzymes and ion channels, except for 5-HT2A (IC50 = 360 nM antagonist), 5-HT2B (EC50 = 67 nM antagonist), 5-HT1A and 5-HT6 (functional activity not tested).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 282.39
Formula C17H22N4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1065110-43-1
PubChem ID 90644511
Smiles C[C@@H]1C2=NC(CC3=CC=CC=C3)=NC(NC)=C2CCNC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.24 100
ethanol 28.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 282.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.41 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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References are publications that support the biological activity of the product.

Storer et al (2014) Multiparameter optimization in CNS drug discovery: Design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT2C) receptor agonists with exquisite functional selectivity over 5-HT2A and 5-HT2B receptors. J.Med.Chem. 57 5258 PMID: 24878222

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