Pep 2-8

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Cat.No. 6423 - Pep 2-8 | Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH2 | CAS No. 1541011-97-5
Description: Potent PCSK9 inhibitor
Literature (1)

Biological Activity

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.

Technical Data

M. Wt 1715.88
Formula C83H110N16O24

(Modifications: Thr-1 = N-terminal Ac, Val-13 = C-terminal amide)

Storage Store at -20°C
CAS Number 1541011-97-5
PubChem ID 124221781
Smiles CC(C)C[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in PBS (pH 7.4)

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Zhang et al (2014) Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem. 289 942 PMID: 24225950

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Keywords: Pep 2-8, Pep 2-8 supplier, PCSK9, inhibitors, inhibits, Proprotein, convertase, subtilsin/kexin, type, 9, Other, Proteases, 6423, Tocris Bioscience

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Literature in this Area

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