Pep 2-8

Pricing Availability Delivery Time Qty
Cat.No. 6423 - Pep 2-8 | Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH2 | CAS No. 1541011-97-5
Description: Potent PCSK9 inhibitor
Datasheet
Citations
Reviews
Literature

Biological Activity

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.

Technical Data

M. Wt 1715.88
Formula C83H110N16O24
Sequence TVFTSWEEYLDWV

(Modifications: Thr-1 = N-terminal Ac, Val-13 = C-terminal amide)

Storage Store at -20°C
CAS Number 1541011-97-5
Smiles CC(C)C[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in PBS (pH 7.4)

Preparing Stock Solutions

The following data is based on the product molecular weight 1715.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.58 mL 2.91 mL 5.83 mL
5 mM 0.12 mL 0.58 mL 1.17 mL
10 mM 0.06 mL 0.29 mL 0.58 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zhang et al (2014) Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem. 289 942 PMID: 24225950


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Keywords: Pep 2-8, supplier, PCSK9, inhibitors, inhibits, Proprotein, convertase, subtilsin/kexin, type, 9, Other, Proteases, Other, Proteases, Tocris Bioscience

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Literature in this Area

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