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Biological Activity for Pep 2-8
Pep 2-8 is a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
Technical Data for Pep 2-8
(Modifications: Thr-1 = N-terminal Ac, Val-13 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pep 2-8
|Solubility||Soluble to 2 mg/ml in PBS (pH 7.4)|
References for Pep 2-8
References are publications that support the biological activity of the product.
Zhang et al (2014) Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem. 289 942 PMID: 24225950
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Keywords: Pep 2-8, Pep 2-8 supplier, PCSK9, inhibitors, inhibits, Proprotein, convertase, subtilsin/kexin, type, 9, Other, Proteases, 6423, Tocris Bioscience
Citations for Pep 2-8
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