Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
(Modifications: Thr-1 = N-terminal Ac, Val-13 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in PBS (pH 7.4)|
Preparing Stock Solutions
The following data is based on the product molecular weight 1715.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.58 mL||2.91 mL||5.83 mL|
|5 mM||0.12 mL||0.58 mL||1.17 mL|
|10 mM||0.06 mL||0.29 mL||0.58 mL|
|50 mM||0.01 mL||0.06 mL||0.12 mL|
References are publications that support the products' biological activity.
Zhang et al (2014) Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem. 289 942 PMID: 24225950
If you know of a relevant reference for Pep 2-8, please let us know.
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Keywords: Pep 2-8, supplier, PCSK9, inhibitors, inhibits, Proprotein, convertase, subtilsin/kexin, type, 9, Other, Proteases, Other, Proteases, Tocris Bioscience
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