Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
(Modifications: Thr-1 = N-terminal Ac, Val-13 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in PBS (pH 7.4)|
References are publications that support the biological activity of the product.
Zhang et al (2014) Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem. 289 942 PMID: 24225950
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Keywords: Pep 2-8, Pep 2-8 supplier, PCSK9, inhibitors, inhibits, Proprotein, convertase, subtilsin/kexin, type, 9, Other, Proteases, 6423, Tocris Bioscience
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